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Background <p>To investigate the value of virtual magnetic resonance elastography (vMRE), fractional order calculus (FROC) model, and diffusion-weighted imaging (DWI) in differentiating rectal cancer grades.</p> Methods <p>This prospective study included 74 patients with rectal cancer who underwent a pelvic MRI. The Mann–Whitney U test or independent samples t-test was employed to compare the parameters of vMRE (µ<sub>MRE</sub>), the FROC model (D, β, and µ), and DWI (ADC). Logistic regression analysis and area under the receiver operating characteristic curve (AUC) were utilized separately for multiparameter co-diagnosis and to assess diagnostic performance. Pearson’s correlation analysis was conducted to evaluate the relationship of different parameters.</p> Results <p>Compared to the low-grade group, the high-grade group had higher µ<sub>MRE</sub> and µ values and lower D, β, and ADC values (all <i>P</i> &lt; 0.05). In terms of the different parameters, the D value demonstrated the highest diagnostic efficacy with an AUC of 0.852(95% CI: 0.750–0.924). In terms of the various methods, the FROC model (D + β + µ) had the highest diagnostic performance with an AUC of 0.943(95% CI: 0.864–0.984), which was significantly higher than those of DWI and vMRE (Z = 3.586, 2.430, and 2.081, all <i>P</i> &lt; 0.05). µ<sub>MRE</sub> showed moderately negative correlations with ADC, D, and β (<i>r</i> = − 0.553, − 0.683, and − 0.530, respectively, all <i>P</i> &lt; 0.05) and a moderately positive correlation with µ (<i>r</i> = 0.443, <i>P</i> &lt; 0.05).</p> Conclusion <p>FROC, vMRE, and DWI can be utilized for assessing rectal cancer grades, with FROC offering comparatively better diagnostic performance.</p>

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Differentiating rectal cancer grades using virtual magnetic resonance elastography and fractional order calculus diffusion model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月18日

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  • Shuaina Wang,
  • Xingxing Jin,
  • Yiwen Ba,
  • Wenling Liu,
  • Jipeng Ren,
  • Lunpu Ai,
  • Hao Li,
  • Fengmei Zhou,
  • Dongming Han,
  • Kaiyu Wang,
  • Ruifang Yan

摘要

Background

To investigate the value of virtual magnetic resonance elastography (vMRE), fractional order calculus (FROC) model, and diffusion-weighted imaging (DWI) in differentiating rectal cancer grades.

Methods

This prospective study included 74 patients with rectal cancer who underwent a pelvic MRI. The Mann–Whitney U test or independent samples t-test was employed to compare the parameters of vMRE (µMRE), the FROC model (D, β, and µ), and DWI (ADC). Logistic regression analysis and area under the receiver operating characteristic curve (AUC) were utilized separately for multiparameter co-diagnosis and to assess diagnostic performance. Pearson’s correlation analysis was conducted to evaluate the relationship of different parameters.

Results

Compared to the low-grade group, the high-grade group had higher µMRE and µ values and lower D, β, and ADC values (all P < 0.05). In terms of the different parameters, the D value demonstrated the highest diagnostic efficacy with an AUC of 0.852(95% CI: 0.750–0.924). In terms of the various methods, the FROC model (D + β + µ) had the highest diagnostic performance with an AUC of 0.943(95% CI: 0.864–0.984), which was significantly higher than those of DWI and vMRE (Z = 3.586, 2.430, and 2.081, all P < 0.05). µMRE showed moderately negative correlations with ADC, D, and β (r = − 0.553, − 0.683, and − 0.530, respectively, all P < 0.05) and a moderately positive correlation with µ (r = 0.443, P < 0.05).

Conclusion

FROC, vMRE, and DWI can be utilized for assessing rectal cancer grades, with FROC offering comparatively better diagnostic performance.