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Background <p>Wilms tumor, a prevalent pediatric kidney cancer, has been extensively studied to elucidate its genetic mechanisms. <i>NAT10</i> (<i>N-acetyltransferase 10</i>) is a gene encoding acetyltransferase, which is involved in various cellular processes, including RNA modification, DNA repair, and protein acetylation. The oncogenic role of NAT10 in cancer has garnered significant attention. However, research on <i>NAT10</i> genetic variants and their associations with cancer is nascent.</p> Methods <p>This study investigated the link between <i>NAT10</i> genetic variants and Wilms tumor risk via a case‒control design with genomic DNA from 414 patients and 1199 controls. Genotyping was performed via the TaqMan method, and logistic regression statistical analysis was conducted to identify significant associations, followed by extra analysis to minimize false positive significant results.</p> Results <p>Our findings revealed that the rs8187 G &gt; A polymorphism in the <i>NAT10</i> gene is significantly correlated with a decreased risk of developing Wilms tumor (GA vs. GG, adjusted odds ratio (AOR) = 0.60, 95% confidence interval (CI) = 0.46–0.77, <i>P</i> &lt; 0.0001; GA/AA vs. GG, AOR = 0.74, 95% CI = 0.59–0.93, <i>P</i> = 0.011). Stratified analyses further revealed a significant association in children aged 18 months or under and in subgroups with stage II, stage IV, or combined stage I + II tumors.</p> Conclusion <p>These results highlight the potential of <i>NAT10</i> rs8187 G &gt; A polymorphism as genetic markers for Wilms tumor susceptibility. This study clarifies the genetic basis of Wilms tumor susceptibility and highlights the role of <i>NAT10</i> rs8187 G &gt; A polymorphism in early detection and risk assessment.</p>

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Association between NAT10 gene rs8187 G > A polymorphism and Wilms tumor susceptibility in Chinese Han children: a five-center case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月17日

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  • Changmi Deng,
  • Jinhong Zhu,
  • Fei Duan,
  • Wenli Zhang,
  • Haixia Zhou,
  • Suhong Li,
  • Jiao Zhang,
  • Jiwen Cheng,
  • Wen Fu,
  • Jing He,
  • Huizhong Niu,
  • Rui-Xi Hua

摘要

Background

Wilms tumor, a prevalent pediatric kidney cancer, has been extensively studied to elucidate its genetic mechanisms. NAT10 (N-acetyltransferase 10) is a gene encoding acetyltransferase, which is involved in various cellular processes, including RNA modification, DNA repair, and protein acetylation. The oncogenic role of NAT10 in cancer has garnered significant attention. However, research on NAT10 genetic variants and their associations with cancer is nascent.

Methods

This study investigated the link between NAT10 genetic variants and Wilms tumor risk via a case‒control design with genomic DNA from 414 patients and 1199 controls. Genotyping was performed via the TaqMan method, and logistic regression statistical analysis was conducted to identify significant associations, followed by extra analysis to minimize false positive significant results.

Results

Our findings revealed that the rs8187 G > A polymorphism in the NAT10 gene is significantly correlated with a decreased risk of developing Wilms tumor (GA vs. GG, adjusted odds ratio (AOR) = 0.60, 95% confidence interval (CI) = 0.46–0.77, P < 0.0001; GA/AA vs. GG, AOR = 0.74, 95% CI = 0.59–0.93, P = 0.011). Stratified analyses further revealed a significant association in children aged 18 months or under and in subgroups with stage II, stage IV, or combined stage I + II tumors.

Conclusion

These results highlight the potential of NAT10 rs8187 G > A polymorphism as genetic markers for Wilms tumor susceptibility. This study clarifies the genetic basis of Wilms tumor susceptibility and highlights the role of NAT10 rs8187 G > A polymorphism in early detection and risk assessment.