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Background <p>To investigate potential predictive factors and assess the utility of systemic inflammatory and nutritional indexes as prognostic indicators for survival in patients with FIGO stage III-IVA squamous cervical cancer (squamous HR-LACC) treated with concurrent chemoradiotherapy.</p> Methods <p>We included consecutive patients with PET-CT diagnosed squamous HR-LACC undergoing curative chemoradiotherapy from November 2016 to April 2024. We systematically reviewed data pertaining to pretreatment clinicopathologic characteristics, hematological parameters, and treatment specifics. A range of composite inflammatory and nutritional indices were calculated, including the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic immune-inflammation index, systemic inflammation response index, pan-immune-inflammation value, and prognostic nutritional index (PNI). X-Tile software was utilized to establish optimal cut-off values based on progression-free survival (PFS). Both univariate and multivariate Cox regression analyses were conducted to identify factors associated with PFS and overall survival (OS).</p> Results <p>Among 157 patients (median age 55) included, 136 had lymph node involvement, and 45 had para-aortic metastasis. After a median follow-up of 35 months, 47 patients had disease progression, and 22 died, yielding 3-year PFS and OS rates of 66.2% and 82.0%, respectively. Multivariate analysis revealed that low SCC-Ag (HR: 1.518, 95% CI: 1.067–2.159, <i>p</i> = 0.020), para-aortic lymph node involvement (HR: 1.864, 95% CI: 1.020–3.408, <i>p</i> = 0.043), and low PNI (HR: 1.477, 95% CI: 1.105–1.975, <i>p</i> = 0.009) were independently associated with worse PFS, whereas low PNI emerged as the sole independent risk factor for diminished OS (HR = 1.525, 95% CI: 1.002–2.323, <i>p</i> = 0.049).</p> Conclusions <p>PNI, a readily obtainable metric based on albumin and lymphocyte count, can serve as a predictor of survival in HR-LACC patients undergoing concurrent chemoradiotherapy. Further research is necessary to ascertain whether optimizing pretreatment nutritional status, a modifiable factor, can enhance outcomes in these high-risk patients.</p>

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Low pretreatment prognostic nutritional index predicts unfavorable survival in stage III-IVA squamous cervical cancer undergoing chemoradiotherapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月28日

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  • Shuang-zheng Jia,
  • Xue-jiao Yang,
  • Duan Yang,
  • Rui Wang,
  • Xi Yang,
  • Man-ni Huang,
  • Ju-sheng An

摘要

Background

To investigate potential predictive factors and assess the utility of systemic inflammatory and nutritional indexes as prognostic indicators for survival in patients with FIGO stage III-IVA squamous cervical cancer (squamous HR-LACC) treated with concurrent chemoradiotherapy.

Methods

We included consecutive patients with PET-CT diagnosed squamous HR-LACC undergoing curative chemoradiotherapy from November 2016 to April 2024. We systematically reviewed data pertaining to pretreatment clinicopathologic characteristics, hematological parameters, and treatment specifics. A range of composite inflammatory and nutritional indices were calculated, including the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic immune-inflammation index, systemic inflammation response index, pan-immune-inflammation value, and prognostic nutritional index (PNI). X-Tile software was utilized to establish optimal cut-off values based on progression-free survival (PFS). Both univariate and multivariate Cox regression analyses were conducted to identify factors associated with PFS and overall survival (OS).

Results

Among 157 patients (median age 55) included, 136 had lymph node involvement, and 45 had para-aortic metastasis. After a median follow-up of 35 months, 47 patients had disease progression, and 22 died, yielding 3-year PFS and OS rates of 66.2% and 82.0%, respectively. Multivariate analysis revealed that low SCC-Ag (HR: 1.518, 95% CI: 1.067–2.159, p = 0.020), para-aortic lymph node involvement (HR: 1.864, 95% CI: 1.020–3.408, p = 0.043), and low PNI (HR: 1.477, 95% CI: 1.105–1.975, p = 0.009) were independently associated with worse PFS, whereas low PNI emerged as the sole independent risk factor for diminished OS (HR = 1.525, 95% CI: 1.002–2.323, p = 0.049).

Conclusions

PNI, a readily obtainable metric based on albumin and lymphocyte count, can serve as a predictor of survival in HR-LACC patients undergoing concurrent chemoradiotherapy. Further research is necessary to ascertain whether optimizing pretreatment nutritional status, a modifiable factor, can enhance outcomes in these high-risk patients.