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Background <p>To evaluate the effect of maternal COVID-19 infection on oxidative stress indicators in the umbilical cord.</p> Methods <p>This was a prospective study. The umbilical cord oxidative stress biomarkers, which include malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI), were compared between COVID-19 positive (study group) and COVID-19 negative mothers (control group).</p> Results <p>There were 25 mothers in each group.Malondialdehyde, TOS, TAS, and OSI values were not associated with maternal age, delivery mode, gestational age, gender, anthropometric measurements, or APGAR scores.Malondialdehyde (26.97 nmol/L [11.14–46.88] vs. 9.93 nmol/L [7.33–13.40], <i>p</i> = 0.001) and TAS (2.13 ± 0.30 mmol/L vs. 1.93 ± 0.19 mmol/L, <i>p</i> = 0.005) values in the study group were significantly higher compared to the control group.The TOS and OSI were similar between the groups.</p> Conclusions <p>Malondialdehyde and TAS were higher in the umbilical cord blood of COVID-19 positive mothers than in healthy controls during the third trimester. Third trimester maternal COVID-19 infection may be associated with increased oxidative stress, accompanied by a compensatory antioxidant response.</p>

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Third-trimester maternal COVID-19 infection and oxidative stress biomarkers in umbilical cord blood

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月1日

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  • Aysun Boga,
  • Asli Okbay Günes,
  • Ezgi Nafile Sayman,
  • Demet Oguz,
  • Timucin Imdadoglu,
  • Nadire Bozköylü Ece,
  • Sirin Güven

摘要

Background

To evaluate the effect of maternal COVID-19 infection on oxidative stress indicators in the umbilical cord.

Methods

This was a prospective study. The umbilical cord oxidative stress biomarkers, which include malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI), were compared between COVID-19 positive (study group) and COVID-19 negative mothers (control group).

Results

There were 25 mothers in each group.Malondialdehyde, TOS, TAS, and OSI values were not associated with maternal age, delivery mode, gestational age, gender, anthropometric measurements, or APGAR scores.Malondialdehyde (26.97 nmol/L [11.14–46.88] vs. 9.93 nmol/L [7.33–13.40], p = 0.001) and TAS (2.13 ± 0.30 mmol/L vs. 1.93 ± 0.19 mmol/L, p = 0.005) values in the study group were significantly higher compared to the control group.The TOS and OSI were similar between the groups.

Conclusions

Malondialdehyde and TAS were higher in the umbilical cord blood of COVID-19 positive mothers than in healthy controls during the third trimester. Third trimester maternal COVID-19 infection may be associated with increased oxidative stress, accompanied by a compensatory antioxidant response.