Scholarlink

<p>This prospective longitudinal study investigated trimester-specific ocular microvascular changes in healthy pregnancy using swept-source optical coherence tomography angiography (SS-OCTA).</p><p>Sixty pregnant women underwent SS-OCTA imaging during early (&lt; 14 weeks), mid- (14–27 weeks), and late pregnancy (&gt; 27 weeks). The study demonstrated: (1) A unique V-shaped trajectory in choroidal vessel density (CVD), with initial decline (86.91 ± 2.01% to 85.77 ± 2.87%, <i>P</i> &lt; 0.001) followed by partial recovery in late pregnancy (85.87 ± 2.82%, <i>P</i> &lt; 0.001 vs. mid-trimester), contrasting with progressive retinal vessel density (RVD) reduction (63.23 ± 3.96% to 58.76 ± 4.26%, <i>P</i> &lt; 0.001); (2) Paradoxical optic nerve changes combining decreased vessel density (73.89 ± 4.37% to 69.48 ± 4.40%, <i>P</i> &lt; 0.001) with increased retinal nerve fiber layer thickness (108.78 ± 10.63&#xa0;μm to 111.30 ± 11.26&#xa0;μm, <i>P</i> = 0.02); (3) Region-specific vulnerability showing most significant changes in the 1–3&#xa0;mm retinal zone.</p><p>These findings provide the first evidence of choroidal vascular adaptation during pregnancy and establish normative trimester-specific benchmarks. The study identifies distinct retinal-choroidal hemodynamic responses, offering new insights into ocular vascular physiology and creating a foundation for detecting pathological deviations in high-risk pregnancies. The choroidal recovery phenomenon may serve as a novel biomarker for circulatory adaptation monitoring.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Gestational ocular microvascular changes in healthy pregnancy: a longitudinal SS-OCTA study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月29日

查看全文
  • Xiaotong Ren,
  • Chenyue Yu,
  • Lijin Cui,
  • Yao Yao,
  • Xiaocui Miao,
  • Jianbo Wu,
  • Jian Guo

摘要

This prospective longitudinal study investigated trimester-specific ocular microvascular changes in healthy pregnancy using swept-source optical coherence tomography angiography (SS-OCTA).

Sixty pregnant women underwent SS-OCTA imaging during early (< 14 weeks), mid- (14–27 weeks), and late pregnancy (> 27 weeks). The study demonstrated: (1) A unique V-shaped trajectory in choroidal vessel density (CVD), with initial decline (86.91 ± 2.01% to 85.77 ± 2.87%, P < 0.001) followed by partial recovery in late pregnancy (85.87 ± 2.82%, P < 0.001 vs. mid-trimester), contrasting with progressive retinal vessel density (RVD) reduction (63.23 ± 3.96% to 58.76 ± 4.26%, P < 0.001); (2) Paradoxical optic nerve changes combining decreased vessel density (73.89 ± 4.37% to 69.48 ± 4.40%, P < 0.001) with increased retinal nerve fiber layer thickness (108.78 ± 10.63 μm to 111.30 ± 11.26 μm, P = 0.02); (3) Region-specific vulnerability showing most significant changes in the 1–3 mm retinal zone.

These findings provide the first evidence of choroidal vascular adaptation during pregnancy and establish normative trimester-specific benchmarks. The study identifies distinct retinal-choroidal hemodynamic responses, offering new insights into ocular vascular physiology and creating a foundation for detecting pathological deviations in high-risk pregnancies. The choroidal recovery phenomenon may serve as a novel biomarker for circulatory adaptation monitoring.