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Objective <p>To investigate serum xenopsin-related peptide (XRP) -1 levels in women with hyperemesis gravidarum (HEG) from the onset of pregnancy until the end of week 14.</p> Materials and methods <p>This cross-sectional study was conducted at the Antalya Training and Research Hospital Obstetrics Clinic, Türkiye, between July and December 2024. Forty-five pregnant diagnosed with HEG and 45 healthy pregnant were included. Venous blood samples for the XRP-1 test were collected from pregnant women and the collected serum samples were stored at -80 degrees until the day of analysis.</p> Results <p>Significant differences were observed between the HEG and healthy groups in terms of serum thyroid-stimulating hormone (1.86 ± 0.54 vs. 1.38 ± 0.67, respectively, <i>p</i> = 0.027), potassium (3.84 ± 0.45 vs. 3.58 ± 0.60, <i>p</i> = 0.010), and XRP-1 (4.33 ± 1.66 vs. 2.38 ± 1.32, <i>p</i> &lt; 0.001) values. At receiver operating characteristic analysis, the area under the curve (AUC: 0.824) was statistically significant for serum XRP-1 (<i>p</i> &lt; 0.001), with a cut-off value of ≥ 2.42 [95% confidence interval 0.731–0.917, 82.2% sensitivity, and 80.0% specificity]. The positive predictive value of serum XRP-1 was 80.0% and the negative predictive value was 81.0%.</p> Conclusion(s) <p>This study suggests that serum XRP-1 levels are elevated in HEG. Further studies are now needed to validate these findings.</p>

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Serum xenopsin-related peptide-1 levels in pregnant women with hyperemesis gravidarum; a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月8日

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  • Bekir Sitki Isenlik,
  • Odul Ozkan Kalfagil,
  • Mehmet Velat Kalfagil,
  • Hamit Yasar Ellidag,
  • Hasan Ali Inal

摘要

Objective

To investigate serum xenopsin-related peptide (XRP) -1 levels in women with hyperemesis gravidarum (HEG) from the onset of pregnancy until the end of week 14.

Materials and methods

This cross-sectional study was conducted at the Antalya Training and Research Hospital Obstetrics Clinic, Türkiye, between July and December 2024. Forty-five pregnant diagnosed with HEG and 45 healthy pregnant were included. Venous blood samples for the XRP-1 test were collected from pregnant women and the collected serum samples were stored at -80 degrees until the day of analysis.

Results

Significant differences were observed between the HEG and healthy groups in terms of serum thyroid-stimulating hormone (1.86 ± 0.54 vs. 1.38 ± 0.67, respectively, p = 0.027), potassium (3.84 ± 0.45 vs. 3.58 ± 0.60, p = 0.010), and XRP-1 (4.33 ± 1.66 vs. 2.38 ± 1.32, p < 0.001) values. At receiver operating characteristic analysis, the area under the curve (AUC: 0.824) was statistically significant for serum XRP-1 (p < 0.001), with a cut-off value of ≥ 2.42 [95% confidence interval 0.731–0.917, 82.2% sensitivity, and 80.0% specificity]. The positive predictive value of serum XRP-1 was 80.0% and the negative predictive value was 81.0%.

Conclusion(s)

This study suggests that serum XRP-1 levels are elevated in HEG. Further studies are now needed to validate these findings.