Scholarlink

Background <p>No consensus has been established for the optimal pre-pregnancy body mass index (BMI) required to reduce the incidence of hypertensive disorders of pregnancy (HDP) in Japanese women. This study investigated the association between the pre-pregnancy BMI range and the prevalence of HDP.</p> Methods <p>Data from 96,796 women with singleton pregnancies at ≥ 22&#xa0;weeks of gestation from the Japan Environment and Children’s Study (enrolled between 2011 and 2014)—a nationwide birth cohort study—were analyzed. The participants were categorized according to pre-pregnancy BMI, as follows: ≤ 16.00, 16.01–17.00, 17.01–18.00, 18.01–19.00, 19.01–20.00, 20.01–21.00, 21.01–22.00, 22.01–23.00, 23.01–24.00, 24.01–25.00, 25.01–26.00, 26.01–27.00, 27.01–28.00, 28.01–29.00, 29.01–30.00, and &gt; 30.00&#xa0;kg/m<sup>2</sup>. Odds ratios (ORs) for HDP were calculated using multivariable regression analysis in each group, with the pre-pregnancy BMI 20.01–21.00&#xa0;kg/m<sup>2</sup> group as the reference group, adjusted for maternal characteristics, followed by the Bonferroni correction. Pre-pregnancy BMI cut-off value for predicting the incidence of HDP was calculated through a receiver operating characteristic (ROC) curve analysis.</p> Results <p>The median pre-pregnancy BMI was 20.52&#xa0;kg/m<sup>2</sup> (interquartile range: 19.07‒22.48&#xa0;kg/m<sup>2</sup>). Adjusted ORs for HDP and severe HDP increased significantly in women with pre-pregnancy BMI &gt; 22.00&#xa0;kg/m<sup>2</sup>, and in those with pre-pregnancy BMI of 24.01–25.00&#xa0;kg/m<sup>2</sup> and BMI &gt; 26.00&#xa0;kg/m<sup>2</sup>, respectively. No changes were observed in those with pre-pregnancy BMI ≤ 20.00&#xa0;kg/m<sup>2</sup>. A pre-pregnancy BMI cut-off value of 22.31&#xa0;kg/m<sup>2</sup> and 22.37&#xa0;kg/m<sup>2</sup> predicted HDP and severe HDP with Youden’s index (sensitivity: 47.1% and 44.0%, specificity: 73.9% and 74.2%) with AUC of 0.63 and 0.62, respectively. Another cut-off value of 32.47&#xa0;kg/m<sup>2</sup> and 32.89&#xa0;kg/m<sup>2</sup> was identified for predicting HDP and severe HDP, respectively, with a specificity &gt; 99%. A similar trend was observed when the analysis was restricted to individuals of Japanese nationality only.</p> Conclusions <p>Pre-pregnancy BMI &gt; 22.00&#xa0;kg/m<sup>2</sup> was associated with an increased prevalence of HDP compared with the pre-pregnancy BMI 20.01–21.00&#xa0;kg/m<sup>2</sup>. Due to the low AUC, we propose that the cut-off BMI values for predicting the incidence of HDP may be used as a supplementary data to identify high-risk populations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pre-pregnancy body mass index range and prevalence of hypertensive disorders of pregnancy: the Japan environment and children’s study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月17日

查看全文
  • Tsuyoshi Murata,
  • Karin Imaizumi,
  • Hirotaka Isogami,
  • Toma Fukuda,
  • Hyo Kyozuka,
  • Shun Yasuda,
  • Akiko Yamaguchi,
  • Akiko Sato,
  • Yuka Ogata,
  • Kosei Shinoki,
  • Mitsuaki Hosoya,
  • Koichi Hashimoto,
  • Hidekazu Nishigori,
  • Seiji Yasumura,
  • Keiya Fujimori,
  • Michihiro Kamijima,
  • Shin Yamazaki,
  • Yukihiro Ohya,
  • Reiko Kishi,
  • Nobuo Yaegashi,
  • Chisato Mori,
  • Shuichi Ito,
  • Zentaro Yamagata,
  • Hidekuni Inadera,
  • Takeo Nakayama,
  • Hiroyasu Iso,
  • Masayuki Shima,
  • Hiroshige Nakamura,
  • Narufumi Suganuma,
  • Koichi Kusuhara,
  • Takahiko Katoh

摘要

Background

No consensus has been established for the optimal pre-pregnancy body mass index (BMI) required to reduce the incidence of hypertensive disorders of pregnancy (HDP) in Japanese women. This study investigated the association between the pre-pregnancy BMI range and the prevalence of HDP.

Methods

Data from 96,796 women with singleton pregnancies at ≥ 22 weeks of gestation from the Japan Environment and Children’s Study (enrolled between 2011 and 2014)—a nationwide birth cohort study—were analyzed. The participants were categorized according to pre-pregnancy BMI, as follows: ≤ 16.00, 16.01–17.00, 17.01–18.00, 18.01–19.00, 19.01–20.00, 20.01–21.00, 21.01–22.00, 22.01–23.00, 23.01–24.00, 24.01–25.00, 25.01–26.00, 26.01–27.00, 27.01–28.00, 28.01–29.00, 29.01–30.00, and > 30.00 kg/m2. Odds ratios (ORs) for HDP were calculated using multivariable regression analysis in each group, with the pre-pregnancy BMI 20.01–21.00 kg/m2 group as the reference group, adjusted for maternal characteristics, followed by the Bonferroni correction. Pre-pregnancy BMI cut-off value for predicting the incidence of HDP was calculated through a receiver operating characteristic (ROC) curve analysis.

Results

The median pre-pregnancy BMI was 20.52 kg/m2 (interquartile range: 19.07‒22.48 kg/m2). Adjusted ORs for HDP and severe HDP increased significantly in women with pre-pregnancy BMI > 22.00 kg/m2, and in those with pre-pregnancy BMI of 24.01–25.00 kg/m2 and BMI > 26.00 kg/m2, respectively. No changes were observed in those with pre-pregnancy BMI ≤ 20.00 kg/m2. A pre-pregnancy BMI cut-off value of 22.31 kg/m2 and 22.37 kg/m2 predicted HDP and severe HDP with Youden’s index (sensitivity: 47.1% and 44.0%, specificity: 73.9% and 74.2%) with AUC of 0.63 and 0.62, respectively. Another cut-off value of 32.47 kg/m2 and 32.89 kg/m2 was identified for predicting HDP and severe HDP, respectively, with a specificity > 99%. A similar trend was observed when the analysis was restricted to individuals of Japanese nationality only.

Conclusions

Pre-pregnancy BMI > 22.00 kg/m2 was associated with an increased prevalence of HDP compared with the pre-pregnancy BMI 20.01–21.00 kg/m2. Due to the low AUC, we propose that the cut-off BMI values for predicting the incidence of HDP may be used as a supplementary data to identify high-risk populations.