Scholarlink

Background <p>It is unclear whether there is an association between maternal abortion history and neonatal outcomes of singleton very preterm infants (VPIs). We assess the association between maternal abortion history and neonatal outcome of VPIs in China.</p> Methods <p>All first parity singleton VPIs born at &lt; 32&#xa0;weeks gestational age (GA) who were admitted to neonatal intensive care units (NICU) participating in the Chinese Neonatal Network (CHNN) from 2019 to 2021 were included in the study. Multivariable logistic regression models were constructed to compare neonatal outcomes among infants with different maternal abortion histories after adjusting for confounders.</p> Results <p>A total of 7256 VPIs were included in this analysis. Overall, 3133 (43.2%) infants had positive maternal abortion history. The incidence of mortality or any major morbidity including respiratory distress syndrome (RDS), patent ductus arteriosus (PDA), intraventricular haemorrhage (IVH), IVH stage 3 or 4, moderate or severe bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), ROP stage 3, 4, or 5 tended to increase significantly with increasing number of maternal abortion histories from non-abortion group to ≥ 2 abortions group. Multivariable analysis showed that maternal abortion history was significantly associated with higher risks of mortality or any major morbidity (adjusted odds ratio [aOR] 1.15, 95% confidence interval [CI] 1.03–1.29), RDS (aOR 1.22, 95%CI 1.08–1.38), IVH (aOR 1.17, 95% CI 1.05–1.31), and IVH stage 3 or 4 (aOR 1.27, 95% CI 1.01–1.59). Risk increased with the number of abortions. VPIs of mothers with two or more abortions had the highest risk of mortality or any major morbidity (aOR 1.18, 95% CI 1.02–1.36), RDS (aOR 1.35, 95% CI 1.18–1.56), IVH (aOR 1.23, 95% CI 1.07–1.43) and moderate or severe BPD (aOR 1.17, 95% CI 1.01–1.36), compared to the non-abortion group.</p> Conclusions <p>In China, VPIs born to mothers with previous abortion history may have a greater risk of adverse outcomes. Based on the potential impact of maternal abortion history on newborns, it is necessary to provide additional information on related risks during antenatal counseling for these mothers.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Associations between maternal abortion history and neonatal outcome among very preterm infants: a multicenter cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月6日

查看全文
  • Min Yang,
  • Jie Yang,
  • Dianna Wang,
  • Jiale Dai,
  • Xiaobo Fan,
  • Yun Cao,
  • Wenhao Zhou,
  • Shoo K. Lee,
  • Jimei Wang,
  • Liyuan Hu,
  • Chao Chen,
  • Lizhong Du,
  • Xiuyong Chen,
  • Huyan Zhang,
  • Xiuying Tian,
  • Jingyun Shi,
  • Zhankui Li,
  • Chuanzhong Yang,
  • Ling Liu,
  • Zuming Yang,
  • Jianhua Fu,
  • Yong Ji,
  • Dongmei Chen,
  • Changyi Yang,
  • Rui Chen,
  • Xiaoming Peng,
  • Ruobing Shan,
  • Shuping Han,
  • Hui Wu,
  • Lili Wang,
  • Qiufen Wei,
  • Mingxia Li,
  • Yiheng Dai,
  • Hong Jiang,
  • Wenqing Kang,
  • Xiaohui Gong,
  • Xiaoyun Zhong,
  • Yuan Shi,
  • Shanyu Jiang,
  • Bing Sun,
  • Long Li,
  • Zhenlang Lin,
  • Jiangqin Liu,
  • Jiahua Pan,
  • Hongping Xia,
  • Xiaoying Li,
  • Falin Xu,
  • Yinping Qiu,
  • Li Ma,
  • Ling Yang,
  • Xiaori He,
  • Yanhong Li,
  • Deyi Zhuang,
  • Qin Zhang,
  • Wenbin Dong,
  • Jianhua Sun,
  • Kun Liang,
  • Huaiyan Wang,
  • Jinxing Feng,
  • Liping Chen,
  • Xinzhu Lin,
  • Chunming Jiang,
  • Chuan Nie,
  • Linkong Zeng,
  • Mingyan Hei,
  • Hongdan Zhu,
  • Hongying Mi,
  • Zhaoqing Yin,
  • Hongxia Song,
  • Hongyun Wang,
  • Dong Li,
  • Yan Gao,
  • Yajuan Wang,
  • Liying Dai,
  • Liyan Zhang,
  • Yangfang Li,
  • Qianshen Zhang,
  • Guofang Ding,
  • Xiaoxia Chen,
  • Zhen Wang,
  • Zheng Tang,
  • Xiaolu Ma,
  • Xiaomei Zhang,
  • Xiaolan Zhang,
  • Fang Wu,
  • Yanxiang Chen,
  • Ying Wu,
  • Joseph Ting

摘要

Background

It is unclear whether there is an association between maternal abortion history and neonatal outcomes of singleton very preterm infants (VPIs). We assess the association between maternal abortion history and neonatal outcome of VPIs in China.

Methods

All first parity singleton VPIs born at < 32 weeks gestational age (GA) who were admitted to neonatal intensive care units (NICU) participating in the Chinese Neonatal Network (CHNN) from 2019 to 2021 were included in the study. Multivariable logistic regression models were constructed to compare neonatal outcomes among infants with different maternal abortion histories after adjusting for confounders.

Results

A total of 7256 VPIs were included in this analysis. Overall, 3133 (43.2%) infants had positive maternal abortion history. The incidence of mortality or any major morbidity including respiratory distress syndrome (RDS), patent ductus arteriosus (PDA), intraventricular haemorrhage (IVH), IVH stage 3 or 4, moderate or severe bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), ROP stage 3, 4, or 5 tended to increase significantly with increasing number of maternal abortion histories from non-abortion group to ≥ 2 abortions group. Multivariable analysis showed that maternal abortion history was significantly associated with higher risks of mortality or any major morbidity (adjusted odds ratio [aOR] 1.15, 95% confidence interval [CI] 1.03–1.29), RDS (aOR 1.22, 95%CI 1.08–1.38), IVH (aOR 1.17, 95% CI 1.05–1.31), and IVH stage 3 or 4 (aOR 1.27, 95% CI 1.01–1.59). Risk increased with the number of abortions. VPIs of mothers with two or more abortions had the highest risk of mortality or any major morbidity (aOR 1.18, 95% CI 1.02–1.36), RDS (aOR 1.35, 95% CI 1.18–1.56), IVH (aOR 1.23, 95% CI 1.07–1.43) and moderate or severe BPD (aOR 1.17, 95% CI 1.01–1.36), compared to the non-abortion group.

Conclusions

In China, VPIs born to mothers with previous abortion history may have a greater risk of adverse outcomes. Based on the potential impact of maternal abortion history on newborns, it is necessary to provide additional information on related risks during antenatal counseling for these mothers.