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Background <p>This systematic review (2018–2023) evaluates the diagnostic accuracy of MCV and MPV in pregnancy-related disorders.</p> Objectives <p>Evaluate diagnostic accuracy of MCV/MPV for pregnancy complications.</p> Methods <p>PRISMA 2020 review of 36 studies (2018–2023) using automated analyzers.</p> Results <p>- MPV &gt; 10.2 fL predicts preeclampsia (78% sensitivity, AUC 0.81).</p> <p>- MCV &lt; 80 fL indicates iron-deficiency anemia (85% specificity).</p> <p>- MPV &gt; 9.8 fL associates with gestational diabetes (OR 2.3, 95% CI 1.8–3.0).</p> <p>- $0.20/test cost advantage.</p> Conclusion <p>These low-cost markers could enhance early detection in resource-limited settings. These hematological markers are associated with up to 60% reduction in diagnostic costs when compared to conventional testing methods, making them viable for LMICs.</p>

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Mean Corpuscular Volume (MCV) and Mean Platelet Volume (MPV) as early diagnostic markers for preeclampsia, gestational diabetes, and anemia: a systematic review of clinical evidence and mechanisms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月3日

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  • Naif Taleb Ali

摘要

Background

This systematic review (2018–2023) evaluates the diagnostic accuracy of MCV and MPV in pregnancy-related disorders.

Objectives

Evaluate diagnostic accuracy of MCV/MPV for pregnancy complications.

Methods

PRISMA 2020 review of 36 studies (2018–2023) using automated analyzers.

Results

- MPV > 10.2 fL predicts preeclampsia (78% sensitivity, AUC 0.81).

- MCV < 80 fL indicates iron-deficiency anemia (85% specificity).

- MPV > 9.8 fL associates with gestational diabetes (OR 2.3, 95% CI 1.8–3.0).

- $0.20/test cost advantage.

Conclusion

These low-cost markers could enhance early detection in resource-limited settings. These hematological markers are associated with up to 60% reduction in diagnostic costs when compared to conventional testing methods, making them viable for LMICs.