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<p>Effects of ambient fine particulate matter (PM<sub>2.5</sub>) chemical constituents on preterm birth (PTB) are inconclusive. We performed a sibling-matched cohort study to explore the association between PM<sub>2.5</sub> constituents and the risk of PTB. Changes in PM<sub>2.5</sub> and the constituents (ΔPM<sub>2.5,</sub> ΔOC, ΔBC, ΔSO<sub>4</sub><sup>2−</sup>, ΔNH<sub>4</sub><sup>+</sup>, ΔNO<sub>3</sub><sup>−</sup>) were calculated as the value at a follow-up pregnancy minus exposures in prior pregnancy. A fixed-effect regression model was used to determine the association of the within-group variation in PM<sub>2.5</sub> total mass and constituents with PTB risk. Gestational age differences within matched siblings were also treated as outcomes. A total of 62,334 sibling pairs were analyzed. We observed that each 10&#xa0;μg/m<sup>3</sup> increase in ΔPM<sub>2.5</sub> in first, second, and third trimester were not statistically significant associated with the risk of PTB, but shortened gestational age was observed, with -0.009&#xa0;week (95% CI: -0.013, -0.005), -0.005 (95% CI: -0.008, -0.002), -0.012 (95%CI: -0.015, -0.008) and -0.019&#xa0;week (95% CI: -0.026, -0.012) decrease in first, second, third and whole pregnancy. Our findings indicate that increase in ambient PM<sub>2.5</sub> constituents was associated with a shorten gestational age. This study added a novel cohort evidence for the association of changes of PM<sub>2.5</sub> components with gestational age.</p>

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Association of ambient fine particulate matter and its chemical constituents with preterm birth: a population-based cohort study with sibling comparison design

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月28日

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  • Hui Chang,
  • Zengli Yu,
  • Yuanfang Zhao,
  • Xiaoan Zhang,
  • Xin Zhao,
  • Cunrui Huang,
  • Huanhuan Zhang

摘要

Effects of ambient fine particulate matter (PM2.5) chemical constituents on preterm birth (PTB) are inconclusive. We performed a sibling-matched cohort study to explore the association between PM2.5 constituents and the risk of PTB. Changes in PM2.5 and the constituents (ΔPM2.5, ΔOC, ΔBC, ΔSO42−, ΔNH4+, ΔNO3−) were calculated as the value at a follow-up pregnancy minus exposures in prior pregnancy. A fixed-effect regression model was used to determine the association of the within-group variation in PM2.5 total mass and constituents with PTB risk. Gestational age differences within matched siblings were also treated as outcomes. A total of 62,334 sibling pairs were analyzed. We observed that each 10 μg/m3 increase in ΔPM2.5 in first, second, and third trimester were not statistically significant associated with the risk of PTB, but shortened gestational age was observed, with -0.009 week (95% CI: -0.013, -0.005), -0.005 (95% CI: -0.008, -0.002), -0.012 (95%CI: -0.015, -0.008) and -0.019 week (95% CI: -0.026, -0.012) decrease in first, second, third and whole pregnancy. Our findings indicate that increase in ambient PM2.5 constituents was associated with a shorten gestational age. This study added a novel cohort evidence for the association of changes of PM2.5 components with gestational age.