Background <p>Unfavorable fetal, neonatal, and maternal outcomes are more likely to occur in pregnancies complicated by hypertension. The degree of awareness regarding health circumstances and locus of control on health is a highly significant component in determining the effectiveness of adherence to therapy, which is influenced by determinant factors.</p> Aim <p>Assess the effectiveness of nursing intervention session on health locus of control and self efficacy for women with preeclampsia.</p> Method <p>Two group quasi-experimental study design was used in outpatient units of all Port Said City obstetric hospitals that adhere to the comprehensive health insurance. A purposive non-probability sample of one hundred and fifty pregnant women. A structured self administered questionnaire, the multidimensional health locus of control scale and general self efficacy scale.</p> Results <p>Following nursing intervention sessions, pregnant women with preeclampsia in study group obtain higher mean score of internal, external powerful others of locus control on health and self efficacy (22.373 ± 9.316, 24.866 ± 7.323 &amp; 15.640 ± 5.116) compared to the control group (20.866 ± 9.969, 23.640 ± 8.105 &amp;12.080 ± 6.803) who didn’t not take part in nurse intervention sessions, with a statistically significant difference (<i>p</i> = 0.000) between the groups under study. Moreover, the study group’s external chance of health locus control mean scores were greater (21.013 ± 9.047) than the control group (19.946 ± 10.628) with none a noticeable difference between the groups under study.</p> Conclusion <p>In women with preeclampsia, nursing intervention can have a positive impact on all aspects of locus of control over health and self efficacy.</p> Trial registration number <p>The study protocol was registered by the Research Ethics Committee of the Faculty of Nursing, Port Said University with code number: NUR27on 9/7/2023.</p>