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Purpose <p>Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are rare mesenchymal neoplasms with unpredictable biological behavior, including a propensity for recurrence and metastasis. Due to their rarity, prognostic factors and optimal management strategies remain incompletely defined. This study aimed to evaluate the clinical characteristics and survival outcomes of patients with CNS SFT.</p> Methods <p>This single-center retrospective study included patients who underwent surgical resection for a presumed meningioma between January 2017 and December 2025 and were postoperatively diagnosed with CNS SFT. Clinical, radiological, surgical, and pathological data were reviewed, and overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan–Meier method.</p> Results <p>Eighteen patients were included (mean age 48.7 years), and gross total resection was achieved in 77.8%. During a median OS follow-up of 28.7 months, three deaths (16.7%) occurred; median OS was not reached. Adjuvant radiotherapy was associated with improved OS (<i>p</i> = 0.027), while postoperative neurological deficits were associated with worse OS (<i>p</i> = 0.011). Seventeen patients were evaluable for DFS, with a median DFS of 9.2 months and a recurrence rate of 64.7%. In multivariable Cox analysis, adjuvant radiotherapy was independently associated with reduced recurrence risk (HR 0.094, <i>p</i> = 0.042).</p> Conclusion <p>CNS SFTs demonstrate favorable overall survival but high early recurrence rates. Adjuvant radiotherapy appears to be associated with improved survival outcomes, underscoring the importance of multidisciplinary management and long-term follow-up.</p>

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Clinical presentation and survival outcome of solitary fibrous tumors of the central nervous system: a single center study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Ahmet Eren Secen,
  • Servet Guresci,
  • Musa Onur Ozbakir,
  • Ugur Kemal Gunduz,
  • Ahmet Deniz Belen

摘要

Purpose

Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are rare mesenchymal neoplasms with unpredictable biological behavior, including a propensity for recurrence and metastasis. Due to their rarity, prognostic factors and optimal management strategies remain incompletely defined. This study aimed to evaluate the clinical characteristics and survival outcomes of patients with CNS SFT.

Methods

This single-center retrospective study included patients who underwent surgical resection for a presumed meningioma between January 2017 and December 2025 and were postoperatively diagnosed with CNS SFT. Clinical, radiological, surgical, and pathological data were reviewed, and overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan–Meier method.

Results

Eighteen patients were included (mean age 48.7 years), and gross total resection was achieved in 77.8%. During a median OS follow-up of 28.7 months, three deaths (16.7%) occurred; median OS was not reached. Adjuvant radiotherapy was associated with improved OS (p = 0.027), while postoperative neurological deficits were associated with worse OS (p = 0.011). Seventeen patients were evaluable for DFS, with a median DFS of 9.2 months and a recurrence rate of 64.7%. In multivariable Cox analysis, adjuvant radiotherapy was independently associated with reduced recurrence risk (HR 0.094, p = 0.042).

Conclusion

CNS SFTs demonstrate favorable overall survival but high early recurrence rates. Adjuvant radiotherapy appears to be associated with improved survival outcomes, underscoring the importance of multidisciplinary management and long-term follow-up.