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Background <p>Patients with acute ischemic stroke from large vessel occlusion (AIS-LVO) require computed tomography(CT) at stroke centers to determine eligibility for endovascular therapy (EVT).However, the performance of prognostic prediction methods using multimodal CT remains unclear. This study aimed to investigate the significance of the mismatch–time ratio (MTR) of CT perfusion imaging (CTP) parameters of conjunction with Alberta Stroke Program Early Computed Tomography Score (ASPECTS) in non-contrast CT (NCCT) for predicting short-term prognosis following EVT in patients with anterior circulation AIS-LVO.</p> Methods <p>Patients with anterior circulation AIS-LVO who underwent EVT at the stroke specialty alliance of the Affiliated Hospital of Xuzhou Medical University from February 2023 to October 2024 were retrospectively were retrospectively included. The mismatch ratio defined by CTP parameters and the ratio of time from onset to CTP (T) were designated as the MTR. Based on the modified Rankin Scale (mRS) at 90 days after EVT, patients were categorized into a favorable prognosis group (mRS ≤ 3) and an adverse prognosis group (mRS &gt; 3). Independent prognostic factors for favorable prognosis at 90 days post-EVT in patients with AIS-LVO were determined by univariate logistic regression and stepwise regression analyses. The predictive performance of MTR alone and the combined predictive efficacy of MTR with ASPECTS was compared via receiver operating characteristic (ROC) curve analysis for prognosis at 90 days post-EVT.</p> Results <p>105 patients were enrolled, comprising 44 in the favorable prognosis group and 61 in the adverse prognosis group. Stepwise regression analysis revealed that MTR (OR = 2.072, <i>P</i> = 0.015, 95% CI: 1.155–3.719) and ASPECTS (OR = 2.363, <i>P</i> = 0.001, 95% CI: 1.445–3.866) were independent predictors of favorable prognosis. ROC curve analysis showed that MTR alone predicted a positive prognosis at 90 days post-EVT for AIS-LVO, with an AUC of 0.778 (<i>P</i> &lt; 0.001). The combination of MTR and ASPECTS predicted a favorable prognosis at 90 days post-EVT for AIS-LVO, yielding an AUC of 0.828 (<i>P</i> &lt; 0.001).</p> Conclusion <p>MTR serves as a novel imaging biomarker indicating positive short-term prognosis for EVT in patients with anterior circulation AIS-LVO. The integration of MTR with ASPECTS enhances the prognostic accuracy of EVT in patients with anterior circulation AIS-LVO.</p>

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Mismatch-time ratio combined with ASPECTS: a novel indicator of favorable prognosis in multimodal ct prediction of anterior circulation large vessel occlusion

  • 期刊论文

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  • 发表日期：

    2026年6月29日

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  • Yan Huang,
  • Chu Zhou,
  • Rongrong Liu,
  • Wei Li,
  • Qiyang Yuan,
  • He Ma,
  • Yukun Wang,
  • Ruicheng Zhang,
  • Chongke Zhong,
  • Ruoyu Qin,
  • Fenfang Gao,
  • Yanbo Cheng,
  • Shiguang Zhu,
  • Deqin Geng

摘要

Background

Patients with acute ischemic stroke from large vessel occlusion (AIS-LVO) require computed tomography(CT) at stroke centers to determine eligibility for endovascular therapy (EVT).However, the performance of prognostic prediction methods using multimodal CT remains unclear. This study aimed to investigate the significance of the mismatch–time ratio (MTR) of CT perfusion imaging (CTP) parameters of conjunction with Alberta Stroke Program Early Computed Tomography Score (ASPECTS) in non-contrast CT (NCCT) for predicting short-term prognosis following EVT in patients with anterior circulation AIS-LVO.

Methods

Patients with anterior circulation AIS-LVO who underwent EVT at the stroke specialty alliance of the Affiliated Hospital of Xuzhou Medical University from February 2023 to October 2024 were retrospectively were retrospectively included. The mismatch ratio defined by CTP parameters and the ratio of time from onset to CTP (T) were designated as the MTR. Based on the modified Rankin Scale (mRS) at 90 days after EVT, patients were categorized into a favorable prognosis group (mRS ≤ 3) and an adverse prognosis group (mRS > 3). Independent prognostic factors for favorable prognosis at 90 days post-EVT in patients with AIS-LVO were determined by univariate logistic regression and stepwise regression analyses. The predictive performance of MTR alone and the combined predictive efficacy of MTR with ASPECTS was compared via receiver operating characteristic (ROC) curve analysis for prognosis at 90 days post-EVT.

Results

105 patients were enrolled, comprising 44 in the favorable prognosis group and 61 in the adverse prognosis group. Stepwise regression analysis revealed that MTR (OR = 2.072, P = 0.015, 95% CI: 1.155–3.719) and ASPECTS (OR = 2.363, P = 0.001, 95% CI: 1.445–3.866) were independent predictors of favorable prognosis. ROC curve analysis showed that MTR alone predicted a positive prognosis at 90 days post-EVT for AIS-LVO, with an AUC of 0.778 (P < 0.001). The combination of MTR and ASPECTS predicted a favorable prognosis at 90 days post-EVT for AIS-LVO, yielding an AUC of 0.828 (P < 0.001).

Conclusion

MTR serves as a novel imaging biomarker indicating positive short-term prognosis for EVT in patients with anterior circulation AIS-LVO. The integration of MTR with ASPECTS enhances the prognostic accuracy of EVT in patients with anterior circulation AIS-LVO.