Scholarlink

Background <p>Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder associated with impaired health-related quality of life. EQ-5D utility and EQ-VAS scores are used in health economic evaluations, but reported estimates vary across MG populations, instruments, tariffs, and study designs.</p> Methods <p>We systematically searched PubMed, Embase, Scopus, and CENTRAL from inception to February 2026. Observational studies and randomized controlled trials reporting baseline or pre-intervention EQ-5D utility or EQ-VAS data in adults with MG were included. Random-effects meta-analyses used restricted maximum likelihood estimation. Subgroup, sensitivity, GRADE-informed certainty, and exploratory aggregate-level meta-regression analyses were performed.</p> Results <p>Ten studies were included. Eight studies (<i>n</i> = 1,514) contributed to EQ-5D utility synthesis, yielding a descriptive pooled mean of 0.74 (95% CI 0.68–0.80), with very high heterogeneity (I² = 95.4%; Cochran Q <i>p</i> &lt; 0.001) and a wide prediction interval (0.52–0.96). Seven studies (<i>n</i> = 2,760) contributed to EQ-VAS synthesis, with a descriptive pooled mean of 66.49 (95% CI 60.99–71.99), very high heterogeneity (I² = 96.3%; Cochran Q <i>p</i> &lt; 0.001), and a wide prediction interval (47.70–85.28). Sensitivity analysis excluding the RCT baseline dataset did not materially change the pooled EQ-5D estimate. In an exploratory analysis based on two studies, utility declined across Myasthenia Gravis Foundation of America (MGFA) classes I–IV. Exploratory meta-regression suggested a possible negative association between mean disease duration and utility, but certainty was very low.</p> Conclusion <p>EQ-5D and EQ-VAS estimates indicate impaired patient-reported health status in MG, but pooled values should be interpreted as low-certainty descriptive summaries, not definitive utility inputs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Patient-reported health utility in adults with myasthenia gravis: a systematic review and meta-analysis of EQ-5D outcomes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月2日

查看全文
  • Venkata Siva Karthik Budumuri,
  • Akshaya Kamalashree G,
  • Hariharan Murugadoss,
  • Vasanth Arun,
  • Aneesh Basheer

摘要

Background

Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder associated with impaired health-related quality of life. EQ-5D utility and EQ-VAS scores are used in health economic evaluations, but reported estimates vary across MG populations, instruments, tariffs, and study designs.

Methods

We systematically searched PubMed, Embase, Scopus, and CENTRAL from inception to February 2026. Observational studies and randomized controlled trials reporting baseline or pre-intervention EQ-5D utility or EQ-VAS data in adults with MG were included. Random-effects meta-analyses used restricted maximum likelihood estimation. Subgroup, sensitivity, GRADE-informed certainty, and exploratory aggregate-level meta-regression analyses were performed.

Results

Ten studies were included. Eight studies (n = 1,514) contributed to EQ-5D utility synthesis, yielding a descriptive pooled mean of 0.74 (95% CI 0.68–0.80), with very high heterogeneity (I² = 95.4%; Cochran Q p < 0.001) and a wide prediction interval (0.52–0.96). Seven studies (n = 2,760) contributed to EQ-VAS synthesis, with a descriptive pooled mean of 66.49 (95% CI 60.99–71.99), very high heterogeneity (I² = 96.3%; Cochran Q p < 0.001), and a wide prediction interval (47.70–85.28). Sensitivity analysis excluding the RCT baseline dataset did not materially change the pooled EQ-5D estimate. In an exploratory analysis based on two studies, utility declined across Myasthenia Gravis Foundation of America (MGFA) classes I–IV. Exploratory meta-regression suggested a possible negative association between mean disease duration and utility, but certainty was very low.

Conclusion

EQ-5D and EQ-VAS estimates indicate impaired patient-reported health status in MG, but pooled values should be interpreted as low-certainty descriptive summaries, not definitive utility inputs.