Scholarlink

Background <p>Retinal microvasculature serves as a promising window to assess cerebral small vessel disease (CSVD). However, the association between comprehensive fundus fluorescein angiography (FFA) biomarkers and the total CSVD burden score remains to be fully elucidated.</p> Aimes <p>To investigate the relationship between the total CSVD burden score and FFA-derived retinal biomarkers, and to identify independent retinal indicators for evaluating CSVD severity.</p> Methods <p>This retrospective study enrolled 120 patients. The CSVD burden score was evaluated based on lacunes of presumed vascular origin, white matter hyperintensities, enlarged perivascular spaces, and cerebral microbleeds. FFA parameters included dynamic hemodynamic indicators (arm-retinal circulation time [ARCT], retinal circulation time [V1-ARCT], retinal venous transit time [V2-V1]) and static vascular caliber indicators (central retinal artery equivalent [CRAE], central retinal vein equivalent [CRVE], arteriolar-to-venular ratio [AVR]), as well as arteriovenous nicking and vascular leakage. Correlation and multivariable regression analyses were performed.</p> Results <p>Across CSVD burden groups, significant differences were detected in age, hypertension, hyperlipidemia, key neuroimaging markers, ARCT, V1-ARCT, CRAE, CRVE, and AVR, whereas gender, diabetes, arteriovenous nicking, vascular leakage, and V2-V1 showed no significant differences. Spearman analysis showed that the CSVD burden score was negatively correlated with CRAE and AVR, and positively correlated with CRVE and V1-ARCT. Multivariable analysis identified CRAE, CRVE, and V1-ARCT as independent factors associated with the CSVD burden score: lower CRAE, higher CRVE, and prolonged V1-ARCT were related to higher CSVD burden.</p> Conclusion <p>Static vascular caliber (CRAE, CRVE) and dynamic retinal circulation time (V1-ARCT) are independently associated with CSVD burden. The combined use of these FFA biomarkers provides a promising tool for the early assessment and noninvasive monitoring of CSVD, supporting further clinical translation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Retinal hemodynamic and caliber biomarkers for the assessment of cerebral small vessel disease burden: insights from fundus fluorescein angiography

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月25日

查看全文
  • Lingxu Xu,
  • Xiangwei Xiong,
  • Yue Zhou,
  • Xiao Zhao,
  • Yutong Wu,
  • Cheng Ye,
  • Zhaoyou Meng

摘要

Background

Retinal microvasculature serves as a promising window to assess cerebral small vessel disease (CSVD). However, the association between comprehensive fundus fluorescein angiography (FFA) biomarkers and the total CSVD burden score remains to be fully elucidated.

Aimes

To investigate the relationship between the total CSVD burden score and FFA-derived retinal biomarkers, and to identify independent retinal indicators for evaluating CSVD severity.

Methods

This retrospective study enrolled 120 patients. The CSVD burden score was evaluated based on lacunes of presumed vascular origin, white matter hyperintensities, enlarged perivascular spaces, and cerebral microbleeds. FFA parameters included dynamic hemodynamic indicators (arm-retinal circulation time [ARCT], retinal circulation time [V1-ARCT], retinal venous transit time [V2-V1]) and static vascular caliber indicators (central retinal artery equivalent [CRAE], central retinal vein equivalent [CRVE], arteriolar-to-venular ratio [AVR]), as well as arteriovenous nicking and vascular leakage. Correlation and multivariable regression analyses were performed.

Results

Across CSVD burden groups, significant differences were detected in age, hypertension, hyperlipidemia, key neuroimaging markers, ARCT, V1-ARCT, CRAE, CRVE, and AVR, whereas gender, diabetes, arteriovenous nicking, vascular leakage, and V2-V1 showed no significant differences. Spearman analysis showed that the CSVD burden score was negatively correlated with CRAE and AVR, and positively correlated with CRVE and V1-ARCT. Multivariable analysis identified CRAE, CRVE, and V1-ARCT as independent factors associated with the CSVD burden score: lower CRAE, higher CRVE, and prolonged V1-ARCT were related to higher CSVD burden.

Conclusion

Static vascular caliber (CRAE, CRVE) and dynamic retinal circulation time (V1-ARCT) are independently associated with CSVD burden. The combined use of these FFA biomarkers provides a promising tool for the early assessment and noninvasive monitoring of CSVD, supporting further clinical translation.