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Background <p>Cognitive and psychiatric impairments are common in patients with frontotemporal meningiomas. While meningiomas are often histologically benign, they can cause significant morbidity through mass effect and peritumoral edema. Compared to gliomas, the reversibility of these impairments following surgical resection is relatively under-investigated. This study aimed to evaluate postoperative neuropsychological changes and identify tumor-related factors associated with recovery in patients with frontotemporal meningiomas.</p> Methods <p>We retrospectively reviewed 29 patients who underwent surgical resection for frontotemporal meningiomas and completed both pre- and postoperative neuropsychological assessments (Neurooncologic Psychological Test [NOPT], Seoul Neuropsychological Screening Battery–II [SNSB-II], or Bundang Neuropsychological Testing Protocol–M1 [BNTP-M1]). Exploratory multivariable linear regression analysis was performed using Δ scores (postoperative minus preoperative) to identify radiologic factors associated with recovery in each domain.</p> Results <p>Postoperatively, patients demonstrated significant improvements across all tested domains: attention (<i>P</i> = 0.002), language (<i>P</i> = 0.041), memory (<i>P</i> &lt; 0.001), visuospatial function (<i>P</i> = 0.024), executive function (<i>P</i> &lt; 0.001), and psychiatric symptoms (<i>P</i> = 0.043). In exploratory multivariable analysis, mass effect was associated with greater improvement in attention (B = 1.33, 95% CI, 0.36 to 2.30; <i>P</i> = 0.009), whereas frontal lobe involvement was associated with less improvement in language function (B = -3.00, 95% CI, -5.06 to -0.94; <i>P</i> = 0.006). Convexity origin was associated with less improvement in Stroop test performance (B = -29.79, 95% CI, -59.48 to -0.11; <i>P</i> = 0.049), and frontal base origin was associated with less improvement in psychiatric symptoms (B = -14.91, 95% CI, -24.83 to -4.98; <i>P</i> = 0.005). Edema index was not significantly associated with executive function recovery in the final exploratory model.</p> Conclusions <p>Neuropsychological impairments in patients with frontotemporal meningiomas demonstrated statistically significant postoperative improvements following surgical resection. Recovery trajectories may be associated with tumor-related factors such as mass effect and anatomical origin. These findings should be interpreted cautiously given the limited sample size and the exploratory nature of the analyses, and support further investigation of tailored rehabilitation strategies based on preoperative radiologic characteristics.</p>

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Reversibility of cognitive and psychiatric impairments following surgical resection of frontotemporal meningiomas: a predictive factor analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月20日

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  • Kahyen Ko,
  • Yoo-Jin Park,
  • Kihwan Hwang,
  • Young Ho Park,
  • Nayoung Ryoo,
  • Min Jae Baek,
  • Jung Ho Han,
  • SangYun Kim,
  • Chae-Yong Kim

摘要

Background

Cognitive and psychiatric impairments are common in patients with frontotemporal meningiomas. While meningiomas are often histologically benign, they can cause significant morbidity through mass effect and peritumoral edema. Compared to gliomas, the reversibility of these impairments following surgical resection is relatively under-investigated. This study aimed to evaluate postoperative neuropsychological changes and identify tumor-related factors associated with recovery in patients with frontotemporal meningiomas.

Methods

We retrospectively reviewed 29 patients who underwent surgical resection for frontotemporal meningiomas and completed both pre- and postoperative neuropsychological assessments (Neurooncologic Psychological Test [NOPT], Seoul Neuropsychological Screening Battery–II [SNSB-II], or Bundang Neuropsychological Testing Protocol–M1 [BNTP-M1]). Exploratory multivariable linear regression analysis was performed using Δ scores (postoperative minus preoperative) to identify radiologic factors associated with recovery in each domain.

Results

Postoperatively, patients demonstrated significant improvements across all tested domains: attention (P = 0.002), language (P = 0.041), memory (P < 0.001), visuospatial function (P = 0.024), executive function (P < 0.001), and psychiatric symptoms (P = 0.043). In exploratory multivariable analysis, mass effect was associated with greater improvement in attention (B = 1.33, 95% CI, 0.36 to 2.30; P = 0.009), whereas frontal lobe involvement was associated with less improvement in language function (B = -3.00, 95% CI, -5.06 to -0.94; P = 0.006). Convexity origin was associated with less improvement in Stroop test performance (B = -29.79, 95% CI, -59.48 to -0.11; P = 0.049), and frontal base origin was associated with less improvement in psychiatric symptoms (B = -14.91, 95% CI, -24.83 to -4.98; P = 0.005). Edema index was not significantly associated with executive function recovery in the final exploratory model.

Conclusions

Neuropsychological impairments in patients with frontotemporal meningiomas demonstrated statistically significant postoperative improvements following surgical resection. Recovery trajectories may be associated with tumor-related factors such as mass effect and anatomical origin. These findings should be interpreted cautiously given the limited sample size and the exploratory nature of the analyses, and support further investigation of tailored rehabilitation strategies based on preoperative radiologic characteristics.