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<p>Orofacial pain syndromes are a heterogenous group of pain disorders resulting in substantial morbidity. They are often refractory to medical treatment and can have an enormous impact on quality of life. Central sensitization plays a major role in chronic pain disorders and poses a diagnostic and therapeutic challenge. Transcranial magnetic resonance-guided focused ultrasound bilateral medial thalamotomy is an emerging treatment in chronic pain syndromes with central sensitization. We here describe a 76-year-old female patient with a long history of atypical orofacial pain and central sensitization with a significant, but temporary regression of the latter after medial thalamotomy using bilateral focused ultrasound.</p>

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Regression of central sensitization after bilateral focused ultrasound medial thalamotomies in atypical orofacial pain? – a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月18日

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  • Matus Velicky Buecheler,
  • Lukasz Kolakowski,
  • Marie Therese Kleinsorge,
  • Heiko Pohl,
  • Lennart Stieglitz,
  • Susanne Wegener

摘要

Orofacial pain syndromes are a heterogenous group of pain disorders resulting in substantial morbidity. They are often refractory to medical treatment and can have an enormous impact on quality of life. Central sensitization plays a major role in chronic pain disorders and poses a diagnostic and therapeutic challenge. Transcranial magnetic resonance-guided focused ultrasound bilateral medial thalamotomy is an emerging treatment in chronic pain syndromes with central sensitization. We here describe a 76-year-old female patient with a long history of atypical orofacial pain and central sensitization with a significant, but temporary regression of the latter after medial thalamotomy using bilateral focused ultrasound.