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Objective <p>The role of diet in multiple sclerosis (MS) development is still a matter of debate and its impact on MS course is not well understood. We tried to investigate the possible role of adolescent diet in late-onset multiple sclerosis (LOMS) odds.</p> Methods <p>LOMS patients were obtained from the National MS Registry of Iran. Controls were sex and age matched with no history of neurological disorders. We assessed dietary factors using a questionnaire based on multinational studies. Food consumption levels were classified into low, medium, and high for each item. Logistic regression models were used to evaluate diet's impact on LOMS odds.</p> Results <p>We included 83 LOMS cases and 207 matched healthy controls. The mean age for LOMS patients was 61.14, compared to 61.51 years for controls. The results showed that higher consumption of dairy as in the third tertile associated with 79% decline in LOMS odds (AOR: 0.21; 95%CI: 0.09–0.47). Higher seafood consumption, in the third tertile was associated with a decrease in the odds of LOMS (AOR: 0.32; 95%CI: 0.14–0.72). Furthermore, increased nut consumption, in the third tertile (AOR: 0.37; 95%CI: 0.18–0.77), decreased the odds of LOMS. Additionally, higher consumption of fruits (AOR: 0.22; 95%CI: 0.07–0.63) and vegetables (AOR: 0.26; 95%CI: 0.12–0.55) was linked to a reduced odds of LOMS.</p> Conclusion <p>This research highlights the advantageous impact of dairy products, seafood, nuts, fruits, and vegetables in lowering the LOMS odds. Hence, advocating for nutrition role in development of LOMS could represent a preventive measure for people susceptible to MS.</p>

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The influence of adolescent diet on the occurrence of late-onset multiple sclerosis: a population-based case–control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月2日

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  • Naghmeh Abbasi Kasbi,
  • Nasim Rezaeimanesh,
  • Sanaz Khodadadi,
  • Sahar Nikkhah Bahrami,
  • Kosar Kohandel,
  • Sajjad Ghane Ezabadi,
  • Faezeh Khodaie,
  • Amir Hossein Sahraian,
  • Melika Arab Bafrani,
  • Sharareh Eskandarieh,
  • Mohammad Ali Sahraian

摘要

Objective

The role of diet in multiple sclerosis (MS) development is still a matter of debate and its impact on MS course is not well understood. We tried to investigate the possible role of adolescent diet in late-onset multiple sclerosis (LOMS) odds.

Methods

LOMS patients were obtained from the National MS Registry of Iran. Controls were sex and age matched with no history of neurological disorders. We assessed dietary factors using a questionnaire based on multinational studies. Food consumption levels were classified into low, medium, and high for each item. Logistic regression models were used to evaluate diet's impact on LOMS odds.

Results

We included 83 LOMS cases and 207 matched healthy controls. The mean age for LOMS patients was 61.14, compared to 61.51 years for controls. The results showed that higher consumption of dairy as in the third tertile associated with 79% decline in LOMS odds (AOR: 0.21; 95%CI: 0.09–0.47). Higher seafood consumption, in the third tertile was associated with a decrease in the odds of LOMS (AOR: 0.32; 95%CI: 0.14–0.72). Furthermore, increased nut consumption, in the third tertile (AOR: 0.37; 95%CI: 0.18–0.77), decreased the odds of LOMS. Additionally, higher consumption of fruits (AOR: 0.22; 95%CI: 0.07–0.63) and vegetables (AOR: 0.26; 95%CI: 0.12–0.55) was linked to a reduced odds of LOMS.

Conclusion

This research highlights the advantageous impact of dairy products, seafood, nuts, fruits, and vegetables in lowering the LOMS odds. Hence, advocating for nutrition role in development of LOMS could represent a preventive measure for people susceptible to MS.