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Background <p>Focal segmental glomerulosclerosis (FSGS) and autoimmune nodopathy (AN) exhibit specific associations with anti-NF186 antibodies, which may act as circulating factors contributing to the development of both conditions. However, these cases are very rare, and the underlying pathogenesis mechanisms remain unclear.</p> Case presentation <p>Here, we report a 63-year-old male patient presented with concurrent FSGS and AN, tested positive for anti-NF186 antibodies. Following the administration of plasma exchange and corticosteroid therapy, both neuropathy and nephropathy exhibited significant improvement. He has achieved a favorable outcome following a seven-month of corticosteroid treatment.</p> Conclusions <p>This case highlights that acute onset quadriparesis with respiratory involvement may be observed in concurrent AN and FSGS mediated by anti-NF186 antibodies, suggesting a close association of these symptoms.</p>

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Autoimmune nodopathy and focal segmental glomerulosclerosis mediated by anti-NF186 antibody: a case report and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月22日

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  • Yang Zhang,
  • Naijuan Yao,
  • Jie Yang,
  • Yurong Zou,
  • Ping Zhang,
  • Yunlin Feng

摘要

Background

Focal segmental glomerulosclerosis (FSGS) and autoimmune nodopathy (AN) exhibit specific associations with anti-NF186 antibodies, which may act as circulating factors contributing to the development of both conditions. However, these cases are very rare, and the underlying pathogenesis mechanisms remain unclear.

Case presentation

Here, we report a 63-year-old male patient presented with concurrent FSGS and AN, tested positive for anti-NF186 antibodies. Following the administration of plasma exchange and corticosteroid therapy, both neuropathy and nephropathy exhibited significant improvement. He has achieved a favorable outcome following a seven-month of corticosteroid treatment.

Conclusions

This case highlights that acute onset quadriparesis with respiratory involvement may be observed in concurrent AN and FSGS mediated by anti-NF186 antibodies, suggesting a close association of these symptoms.