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Objectives <p>To analyze the factors affecting prognosis of patients with sporadic amyotrophic lateral sclerosis (ALS), to establish a nomogram predictive model.</p> Methods <p>A total of 236 patients with sporadic ALS hospitalized in the Department of Neurology of the First Medical Center, Chinese PLA General Hospital, from March 2011 to November 2021 were enrolled in the study. Basic information and clinical and laboratory data of patients were collected, including sex, age at onset, body mass index, disease duration, diagnostic grade, and serum levels of creatine kinase (CK), creatinine (Cr), uric acid (UA), and ferritin. Kaplan-Meier univariate and multivariate Cox proportional hazard regression models were used to analyze the prognostic factors, and a nomogram predictive model was established.</p> Results <p>Univariate analysis showed that ferritin, CK, Cr, age at onset, disease duration, and body mass index (BMI) were all correlated with prognosis of ALS. Multivariate analysis showed that ferritin, Cr, disease duration, age at onset, and BMI were the strongest predictors. ROC curve and correction curve analyses verified the accuracy of the nomogram prediction model.</p> Conclusions <p>Ferritin, Cr, disease duration, age at onset, and BMI are independent predictors of survival in patients with ALS. Based on these clinical and biological prognostic factors, we established a quantitative model for predicting survival probability, and may assist in the prognostic evaluation of ALS, pending further validation.</p>

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Nomogram prediction model for prognosis of patients with amyotrophic lateral sclerosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月26日

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  • Qionghua Sun,
  • Hongfen Wang,
  • Guochao Deng,
  • Yuguo Du,
  • Tie Ma,
  • Jichao Ding,
  • Zhenxi Xia,
  • Yuqing Jiang,
  • Yonghua Huang,
  • Xusheng Huang

摘要

Objectives

To analyze the factors affecting prognosis of patients with sporadic amyotrophic lateral sclerosis (ALS), to establish a nomogram predictive model.

Methods

A total of 236 patients with sporadic ALS hospitalized in the Department of Neurology of the First Medical Center, Chinese PLA General Hospital, from March 2011 to November 2021 were enrolled in the study. Basic information and clinical and laboratory data of patients were collected, including sex, age at onset, body mass index, disease duration, diagnostic grade, and serum levels of creatine kinase (CK), creatinine (Cr), uric acid (UA), and ferritin. Kaplan-Meier univariate and multivariate Cox proportional hazard regression models were used to analyze the prognostic factors, and a nomogram predictive model was established.

Results

Univariate analysis showed that ferritin, CK, Cr, age at onset, disease duration, and body mass index (BMI) were all correlated with prognosis of ALS. Multivariate analysis showed that ferritin, Cr, disease duration, age at onset, and BMI were the strongest predictors. ROC curve and correction curve analyses verified the accuracy of the nomogram prediction model.

Conclusions

Ferritin, Cr, disease duration, age at onset, and BMI are independent predictors of survival in patients with ALS. Based on these clinical and biological prognostic factors, we established a quantitative model for predicting survival probability, and may assist in the prognostic evaluation of ALS, pending further validation.