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Background <p>Tools to identify patients at high risk for subclinical atherosclerosis (subAS) are lacking. We evaluated the Framingham risk score (FRS) for identifying high-risk subAS patients.</p> Methods <p>We enrolled 68 subAS patients and 150 healthy controls. Carotid intima-media thickness (cIMT) was measured via ultrasound in both common carotid arteries, and FRS was calculated.</p> Results <p>The FRS was low (median, 3.98%). Mean cIMTs for both long and short axes in subAS patients were higher than in healthy individuals (𝑃 &lt; 0.001). In subAS patients, FRS significantly correlated with increased cIMT in long (high-risk OR = 11.61, 95% CI = 2.66–65.95) and short (high-risk OR = 7.11, 95% CI = 1.73–37.79) axes. FRS predicted increased cIMT in long (AUC = 0.713) and short (AUC = 0.673) axes in subAS patients, but not in healthy controls (𝑃 &gt; 0.05).</p> Conclusions <p>FRS is associated with high-risk subAS patients, but complementary noninvasive imaging data are needed.</p>

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Framingham risk score in predicting increased carotid intima-media thickness on ultrasound: identifying patients with subclinical atherosclerosis at high risk

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Weiming Ge,
  • Xuezhong Jiang,
  • Hui Huang,
  • Yating Li,
  • Xiaojing Liu,
  • Rui He,
  • Hui Wang,
  • Zhengqiu Zhu,
  • Ping He,
  • Yinping Wang,
  • Xuehui Ma,
  • Airong Ren,
  • Bixiao Shen,
  • Meijuan Wang,
  • Mingxing Wei

摘要

Background

Tools to identify patients at high risk for subclinical atherosclerosis (subAS) are lacking. We evaluated the Framingham risk score (FRS) for identifying high-risk subAS patients.

Methods

We enrolled 68 subAS patients and 150 healthy controls. Carotid intima-media thickness (cIMT) was measured via ultrasound in both common carotid arteries, and FRS was calculated.

Results

The FRS was low (median, 3.98%). Mean cIMTs for both long and short axes in subAS patients were higher than in healthy individuals (𝑃 < 0.001). In subAS patients, FRS significantly correlated with increased cIMT in long (high-risk OR = 11.61, 95% CI = 2.66–65.95) and short (high-risk OR = 7.11, 95% CI = 1.73–37.79) axes. FRS predicted increased cIMT in long (AUC = 0.713) and short (AUC = 0.673) axes in subAS patients, but not in healthy controls (𝑃 > 0.05).

Conclusions

FRS is associated with high-risk subAS patients, but complementary noninvasive imaging data are needed.