Background <p>Patients undergoing spinal surgery often experience chronic pain and functional limitations. These complications frequently lead to diminished quality of life, hope, and resilience. Inadequate family knowledge regarding home-based patient care exacerbates these challenges. This study investigates the effect of family support through education and follow-up after discharge on the quality of life, resilience, and hope in patients following spinal surgery.</p> Methods <p>This quasi-experimental study was conducted on 50 spinal surgery patients in Hamadan from November 2023 to October 2024. Participants were selected through convenience sampling and randomly allocated to either intervention or control groups. The intervention group received two visual training sessions before discharge and one month of follow-up, while the control group received only routine care. Data were collected using SF-36 (Quality of Life), MHS (Hope), and CD-RISC (Resilience) questionnaires. Finally, the data were analyzed using Independent and Paired t-tests, Chi-square, and ANCOVA at the significance level of <i>P</i> &lt; 0.05 in SPSS 24.</p> Results <p>The groups showed no significant differences in baseline characteristics (<i>P</i> &gt; 0.05). Post-intervention, the intervention group demonstrated significantly higher scores in quality of life (<i>P</i> = 0.013, Cohen’s d = 0.73, 95% CI [0.21–1.25]) and resilience (<i>P</i> = 0.01, d = 0.76, 95% CI [0.25–1.27]) compared to controls, indicating medium-to-large effect sizes. No significant difference was found for hope (<i>P</i> = 0.543, d = 0.17, 95% CI [-0.18, 0.52]).</p> Conclusion <p>Family education and post-discharge follow-up improved quality of life and resilience in spinal surgery patients, though no significant effect was observed on hope. These findings underscore the importance of structured family caregiving support and systematic follow-up in enhancing patient outcomes.</p>