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<p>FOLFOX (folinic acid, 5-fluorouracil, and oxaliplatin) chemotherapy regimen is a widely used chemotherapy agent for the management of gastrointestinal malignancies. FOLFOX has been linked to various toxicities including peripheral neurotoxicity. We report a case of central neurotoxicity demonstrated clinically and radiographically within 24&#xa0;h of FOLFOX administration in a patient with metastatic gastric adenocarcinoma. We further review these clinical and radiographic characteristics to help guide treatment and management of these patients.</p>

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A case of folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy regimen associated neurotoxicity and review of literature

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月25日

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  • Juhi Srivastava,
  • Esha Kataria DO,
  • Sanjeev Sivakumar,
  • Naresh Mullaguri

摘要

FOLFOX (folinic acid, 5-fluorouracil, and oxaliplatin) chemotherapy regimen is a widely used chemotherapy agent for the management of gastrointestinal malignancies. FOLFOX has been linked to various toxicities including peripheral neurotoxicity. We report a case of central neurotoxicity demonstrated clinically and radiographically within 24 h of FOLFOX administration in a patient with metastatic gastric adenocarcinoma. We further review these clinical and radiographic characteristics to help guide treatment and management of these patients.