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Background <p>Sneddon syndrome, a rare, non-inflammatory thrombotic vasculopathy characterized by livedo racemosa and cerebrovascular disease.</p> Case presentation <p>We present a case series of six women diagnosed with Sneddon syndrome. We conducted a thorough analysis of clinical, radiological, and laboratory data, including results of prothrombotic and autoimmune screening. Our findings emphasize the importance of considering Sneddon syndrome as a potential cause of stroke, particularly in young women, and underscore the necessity of a comprehensive dermatological examination when evaluating stroke etiology. Additionally, we provide a comprehensive literature review of the clinical manifestations, radiological and histopathological findings, as well as treatment options.</p> Conclusion <p>A thorough dermatological examination can aid in early detection of Sneddon syndrome and may change the course of treatment of stroke in young adults.</p>

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A case series of Sneddon syndrome: clinical features, diagnostic workup, and literature review

  • 期刊论文

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  • 发表日期：

    2025年11月28日

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  • Bruno Henrique Carneiro Costa Filho,
  • Victor Ting Po Chy,
  • João Augusto de Macedo Cavalcanti de Albuquerque,
  • Pedro Jatobá Arteiro,
  • Davi Alexandre Soares Neves,
  • Mário Luciano de Mélo Silva Júnior,
  • Eduardo Sousa de Melo

摘要

Background

Sneddon syndrome, a rare, non-inflammatory thrombotic vasculopathy characterized by livedo racemosa and cerebrovascular disease.

Case presentation

We present a case series of six women diagnosed with Sneddon syndrome. We conducted a thorough analysis of clinical, radiological, and laboratory data, including results of prothrombotic and autoimmune screening. Our findings emphasize the importance of considering Sneddon syndrome as a potential cause of stroke, particularly in young women, and underscore the necessity of a comprehensive dermatological examination when evaluating stroke etiology. Additionally, we provide a comprehensive literature review of the clinical manifestations, radiological and histopathological findings, as well as treatment options.

Conclusion

A thorough dermatological examination can aid in early detection of Sneddon syndrome and may change the course of treatment of stroke in young adults.