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<p>Nitromidazole antibiotics, exemplified by metronidazole and ornidazole, have been reported to trigger a spectrum of adverse effects. These encompass ataxia, hearing loss, visual impairment, psychomotor dysfunction, intellectual impairment, and epileptic seizures (Rinsho Shinkeigaku 64:637-641, 2024). Nevertheless, cases of involuntary limb tremors have been scarcely documented. Ornidazole, the most recent derivative within this class, boasts a longer half - life and is infrequently linked to limb tremors. This article reports a 63-year-old female patient who developed progressive limb tremors following long-term, high-dose administration of ornidazole, with symptoms gradually alleviating after discontinuation of the drug.</p>

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Ornidazole-induced involuntary tremor in a Chinese woman: a rare case report and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月29日

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  • Hui Wang,
  • Yanling Huang,
  • Xuefei Wang,
  • Fulan Yang,
  • Chunjing Jiang,
  • Yueqin Zhou,
  • Liu Yang

摘要

Nitromidazole antibiotics, exemplified by metronidazole and ornidazole, have been reported to trigger a spectrum of adverse effects. These encompass ataxia, hearing loss, visual impairment, psychomotor dysfunction, intellectual impairment, and epileptic seizures (Rinsho Shinkeigaku 64:637-641, 2024). Nevertheless, cases of involuntary limb tremors have been scarcely documented. Ornidazole, the most recent derivative within this class, boasts a longer half - life and is infrequently linked to limb tremors. This article reports a 63-year-old female patient who developed progressive limb tremors following long-term, high-dose administration of ornidazole, with symptoms gradually alleviating after discontinuation of the drug.