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<p>Subacute sclerosing pan encephalitis (SSPE) is a slow viral disease that follows the wild-type measles infection of early childhood with a subsequent progressive encephalitic illness with seizures and global regression after a long latent period. Mostly considered an invariably progressive and terminal degenerative disorder, the intriguing variability in course with plateaus and spontaneous remissions, while rare, have been recognized [1, 2]. The predictors of disease trajectory and the mechanisms at molecular and immunological levels that determine these differences in outcome remain largely undetermined. Here, we describe a young lady with classical and well-defined features of SSPE who had a relatively favourable outcome with remissions and atypical relapses spread over more than a decade. This highlights the crucial need for detailed documentation and consistent follow-up instead of resorting to a blanket approach of therapeutic pessimism when treating SSPE.</p>

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“Subacute sclerosing panencephalitis: a case report of atypical long-term survivor”

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月23日

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  • Deepak Menon,
  • Abhishek Rathore,
  • Arjun Chandrashekar,
  • Faheem Arshad,
  • Saraswati Nashi,
  • P. R. Srijithesh,
  • Suvarna Alladi

摘要

Subacute sclerosing pan encephalitis (SSPE) is a slow viral disease that follows the wild-type measles infection of early childhood with a subsequent progressive encephalitic illness with seizures and global regression after a long latent period. Mostly considered an invariably progressive and terminal degenerative disorder, the intriguing variability in course with plateaus and spontaneous remissions, while rare, have been recognized [1, 2]. The predictors of disease trajectory and the mechanisms at molecular and immunological levels that determine these differences in outcome remain largely undetermined. Here, we describe a young lady with classical and well-defined features of SSPE who had a relatively favourable outcome with remissions and atypical relapses spread over more than a decade. This highlights the crucial need for detailed documentation and consistent follow-up instead of resorting to a blanket approach of therapeutic pessimism when treating SSPE.