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Background <p>In patients suffering from coronary artery disease, the measured platelet–hemoglobin ratio (PHR) is a key biomarker of prognosis. However, the association between PHR and contrast-induced acute kidney injury (CI-AKI) outcomes after percutaneous coronary intervention (PCI) are unclear.</p> Methods <p>In a retrospective study, 26,479 patients (63.3 ± 11.5 years of age, 22.1% female) who underwent PCI were enrolled. CI-AKI was defined as serum creatinine levels above 0.3&#xa0;mg/dL, exceeding the baseline by more than 50%, in the first 48&#xa0;h following contrast exposure. The relationship between PHR and CI-AKI was clarified through univariate and multivariable logistic regression analyses.</p> Results <p>In summary, CI-AKI occurred in 1,707 patients (6.4%) following PCI. The association of an increased PHR with elevated CI-AKI incidence was determined via multivariate logistic regression analysis (odds ratio for Q4 vs. Q1, 1.42; 95% confidence interval [95% CI], 1.20–1.68; <i>P</i> &lt; 0.001). Restricted cubic spline analysis indicated a linear PHR–CI-AKI relationship (non-linearity <i>P</i> = 0.060).</p> Conclusion <p>A high PHR was strongly correlated with elevated CI-AKI incidence, indicating PHR as a factor independently associated with CI-AKI.</p>

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Association between platelet-to-hemoglobin ratio and contrast-induced acute kidney injury after percutaneous coronary intervention

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月19日

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  • Qiqiang Li,
  • Leigang Tian,
  • Lijian Li,
  • Yingming Shi,
  • Yujing Li,
  • Linxiao Deng,
  • Yong Liu,
  • Kedong Han

摘要

Background

In patients suffering from coronary artery disease, the measured platelet–hemoglobin ratio (PHR) is a key biomarker of prognosis. However, the association between PHR and contrast-induced acute kidney injury (CI-AKI) outcomes after percutaneous coronary intervention (PCI) are unclear.

Methods

In a retrospective study, 26,479 patients (63.3 ± 11.5 years of age, 22.1% female) who underwent PCI were enrolled. CI-AKI was defined as serum creatinine levels above 0.3 mg/dL, exceeding the baseline by more than 50%, in the first 48 h following contrast exposure. The relationship between PHR and CI-AKI was clarified through univariate and multivariable logistic regression analyses.

Results

In summary, CI-AKI occurred in 1,707 patients (6.4%) following PCI. The association of an increased PHR with elevated CI-AKI incidence was determined via multivariate logistic regression analysis (odds ratio for Q4 vs. Q1, 1.42; 95% confidence interval [95% CI], 1.20–1.68; P < 0.001). Restricted cubic spline analysis indicated a linear PHR–CI-AKI relationship (non-linearity P = 0.060).

Conclusion

A high PHR was strongly correlated with elevated CI-AKI incidence, indicating PHR as a factor independently associated with CI-AKI.