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Background <p>Ectopic fat deposition in non-adipose organs is increasingly recognized as a driver of chronic metabolic disease, yet the relationship between intrapancreatic fat and impaired renal function remains poorly defined. We investigated whether pancreatic steatosis, quantified by computed-tomography (CT) attenuation, is independently associated with impaired renal function in a large Chinese health-screening cohort.</p> Methods <p>This cross-sectional study included adults (≥ 20 years) who underwent low-dose chest CT and same-day serum creatinine measurement at the Nanjing University of Chinese Medicine between 2018 and 2021. Pancreatic fat was assessed by mean CT attenuation (PanCT) and the pancreas-to-spleen attenuation ratio (P/S). Impaired renal function was defined as an estimated glomerular filtration rate &lt; 60 mL/min/1.73&#xa0;m².</p> Results <p>Among 9,432 participants (mean age 51.6 ± 15.4 years; 60.7% male), 232 (2.5%) had CKD. Both PanCT and P/S decreased monotonically with increasing impaired renal function prevalence across quartiles (p-trend &lt; 0.001). The highest quartiles of PanCT (&gt; 50.2 HU) and P/S (&gt; 1.03) were associated with 48% (OR 0.52; 95% CI 0.27–0.99) and 54% (OR 0.46; 95% CI 0.23–0.90) lower odds of impaired renal function, respectively, compared with the lowest quartiles. Restricted cubic splines revealed a linear inverse relationship, and subgroup analyses confirmed consistency in non-diabetic, non-hypertensive, and high-liver-fat individuals.</p> Conclusions <p>Greater intrapancreatic fat deposition is independently associated with increased risk of impaired renal function in Chinese adults.</p>

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The association between computed tomography-based intrapancreatic fat deposition and renal function

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月21日

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  • Dingzhe Zhang,
  • Yiping Zhang,
  • Xin Chen,
  • Rui Yu,
  • Hao Zhou,
  • Jianhua Wang,
  • Xiao Chen

摘要

Background

Ectopic fat deposition in non-adipose organs is increasingly recognized as a driver of chronic metabolic disease, yet the relationship between intrapancreatic fat and impaired renal function remains poorly defined. We investigated whether pancreatic steatosis, quantified by computed-tomography (CT) attenuation, is independently associated with impaired renal function in a large Chinese health-screening cohort.

Methods

This cross-sectional study included adults (≥ 20 years) who underwent low-dose chest CT and same-day serum creatinine measurement at the Nanjing University of Chinese Medicine between 2018 and 2021. Pancreatic fat was assessed by mean CT attenuation (PanCT) and the pancreas-to-spleen attenuation ratio (P/S). Impaired renal function was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m².

Results

Among 9,432 participants (mean age 51.6 ± 15.4 years; 60.7% male), 232 (2.5%) had CKD. Both PanCT and P/S decreased monotonically with increasing impaired renal function prevalence across quartiles (p-trend < 0.001). The highest quartiles of PanCT (> 50.2 HU) and P/S (> 1.03) were associated with 48% (OR 0.52; 95% CI 0.27–0.99) and 54% (OR 0.46; 95% CI 0.23–0.90) lower odds of impaired renal function, respectively, compared with the lowest quartiles. Restricted cubic splines revealed a linear inverse relationship, and subgroup analyses confirmed consistency in non-diabetic, non-hypertensive, and high-liver-fat individuals.

Conclusions

Greater intrapancreatic fat deposition is independently associated with increased risk of impaired renal function in Chinese adults.