Background <p>Latent autoimmune diabetes in adults (LADA) is recognized as the most prevalent form of autoimmune diabetes in adulthood marked by a long-term preservation of endogenous insulin secretion capacity. Renal hypouricemia type 2 (RHUC2) is a rare genetic disorder characterized by defective uric acid reabsorption which results from variants in the <i>SLC2A9</i> gene. Currently, there are no reported cases of RHUC2 combined with LADA.</p> Case Presentation <p>A 39-year-old servicewoman visited our hospital with the complaint of elevated blood glucose for 2 years and polydipsia, polyuria, numb right thumb for 4 months. Laboratory tests showed a high value of glucose in both urine and blood, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), glycosylated hemoglobin (HbA1c) and anti-glutamic acid decarboxylase antibody (GADA), and a low value of fasting immunoreactive insulin (IRI) and C-peptide (C-P). She had a history of hypothyroidism for 6 years. Therefore, the patient was initially diagnosed with LADA, primary hypothyroidism and hyperlipidemia. Later, laboratory tests revealed an extremely low level of uric acid and a high value of fractional excretion of uric acid (FE_UA). Two <i>SLC2A9</i> heterozygous mutations, one <i>PPP1R3A</i> heterozygous mutation and one <i>FOXD3</i> variation were found through gene analysis. Finally, the patient was diagnosed with RHUC2, LADA, Hashimoto’s thyroiditis, hyperlipidemia and antiphospholipid syndrome (APS).</p> Conclusion <p>Two <i>SLC2A9</i> heterozygous mutations, c. 227C &gt; A and c. 1343C &gt; T, were identified in the patient. These characteristics indicated that the patient was suffered from RHUC2.</p>