Scholarlink

Background <p>Thrombotic microangiopathy (TMA) is a syndrome characterized by vascular endothelial cell damage, with anemia, thrombocytopenia, and thrombus-related organ damage. Secondary TMA is caused by various factors, including hematological malignancy. Case reports on TMA with mantle cell lymphoma (MCL) are extremely rare. Herein, we report a case of secondary TMA wherein MCL was diagnosed based on the same kidney biopsy specimen and treated with chemotherapy, resulting in improvement in TMA.</p> Case presentation <p>A 60-year-old man was admitted to our hospital for acute kidney injury with TMA and focal interstitial lymphocytic infiltration, which was detected by kidney biopsy performed at a previous hospital. Plasma exchange, hemodialysis, and steroid therapy were initiated; however, the TMA did not improve. Immunostaining of the kidney biopsy specimen revealed MCL; chemotherapy was initiated, which improved the thrombocytopenia and hemolysis.</p> Conclusions <p>To our best knowledge, this is a very rare case of secondary TMA owing to MCL wherein chemotherapy was effective, suggesting a causal relationship. Kidney biopsy was key to identifying the underlying malignancy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Thrombotic microangiopathy associated with mantle cell lymphoma: a case report

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月3日

查看全文
  • Yuri Tonouchi,
  • Koji Hashimoto,
  • Ryohei Iwabuchi,
  • Hitoshi Sakai,
  • Takayuki Nimura,
  • Kosuke Yamaka,
  • Marina Nishikawa,
  • Akinori Yamaguchi,
  • Kosuke Sonoda,
  • Yuji Kamijo

摘要

Background

Thrombotic microangiopathy (TMA) is a syndrome characterized by vascular endothelial cell damage, with anemia, thrombocytopenia, and thrombus-related organ damage. Secondary TMA is caused by various factors, including hematological malignancy. Case reports on TMA with mantle cell lymphoma (MCL) are extremely rare. Herein, we report a case of secondary TMA wherein MCL was diagnosed based on the same kidney biopsy specimen and treated with chemotherapy, resulting in improvement in TMA.

Case presentation

A 60-year-old man was admitted to our hospital for acute kidney injury with TMA and focal interstitial lymphocytic infiltration, which was detected by kidney biopsy performed at a previous hospital. Plasma exchange, hemodialysis, and steroid therapy were initiated; however, the TMA did not improve. Immunostaining of the kidney biopsy specimen revealed MCL; chemotherapy was initiated, which improved the thrombocytopenia and hemolysis.

Conclusions

To our best knowledge, this is a very rare case of secondary TMA owing to MCL wherein chemotherapy was effective, suggesting a causal relationship. Kidney biopsy was key to identifying the underlying malignancy.