Scholarlink

Background <p>Fluid volume overload is a frequent cause of hospitalization for patients with end-stage kidney disease (ESKD), and disproportionately occurs during the 2-day hemodialysis gap when patients are most susceptible to poor volume control. Noninvasive, wearable devices may hold potential for at-home volume status monitoring to prevent hospitalization but clinical validation in ESKD populations is limited.</p> Methods <p>A total of 17 study participants (41% female, 76% Black, median age = 68 years) were recruited for in-center testing of hydration status pre- and post-hemodialysis. Percent lung water (%LW) and skin hydration were noninvasively assessed and compared with established clinical and hemodynamic and markers of hydration status.</p> Results <p>Median within-subject change in systolic blood pressure (-10 mmHg, <i>p</i> = 0.08), diastolic blood pressure (-6 mmHg, <i>p</i> = 0.06), weight (-1.6&#xa0;kg, <i>p</i> &lt; 0.0001), heart rate (-10&#xa0;bpm, <i>p</i> = 0.09), and %LW (-1.0%, <i>p</i> = 0.03) declined from pre- to post-dialysis. When analyzed as a continuous measurement, %LW was not correlated with systolic blood pressure, weight, heart rate, or dyspnea score. Skin hydration demonstrated poor correlation with %LW, but statistically differed (42 vs. 23 a.u.; <i>P</i> = 0.03) when stratified by the broader categories of borderline-high/elevated versus normal %LW, suggesting an ability to detect abnormal fluid status.</p> Conclusion <p>In this small pilot study, noninvasive assessment of %LW was sufficiently sensitive to detect pre-to-post hemodialysis change in fluid status. These results support future evaluations in larger studies of patients with ESKD. Noninvasive, wearable devices may be a feasible strategy to assess volume status in the ESKD population, an approach which could potentially be extended to at-home settings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Noninvasive assessment of volume status in patients with end-stage kidney disease using a wearable monitor and cutaneous hydration sensor

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月10日

查看全文
  • Melissa C. Caughey,
  • Dhatri Kakarla,
  • Sora Lee,
  • Simran K. Singh,
  • Caroline J. Poulton,
  • Emily H. Chang

摘要

Background

Fluid volume overload is a frequent cause of hospitalization for patients with end-stage kidney disease (ESKD), and disproportionately occurs during the 2-day hemodialysis gap when patients are most susceptible to poor volume control. Noninvasive, wearable devices may hold potential for at-home volume status monitoring to prevent hospitalization but clinical validation in ESKD populations is limited.

Methods

A total of 17 study participants (41% female, 76% Black, median age = 68 years) were recruited for in-center testing of hydration status pre- and post-hemodialysis. Percent lung water (%LW) and skin hydration were noninvasively assessed and compared with established clinical and hemodynamic and markers of hydration status.

Results

Median within-subject change in systolic blood pressure (-10 mmHg, p = 0.08), diastolic blood pressure (-6 mmHg, p = 0.06), weight (-1.6 kg, p < 0.0001), heart rate (-10 bpm, p = 0.09), and %LW (-1.0%, p = 0.03) declined from pre- to post-dialysis. When analyzed as a continuous measurement, %LW was not correlated with systolic blood pressure, weight, heart rate, or dyspnea score. Skin hydration demonstrated poor correlation with %LW, but statistically differed (42 vs. 23 a.u.; P = 0.03) when stratified by the broader categories of borderline-high/elevated versus normal %LW, suggesting an ability to detect abnormal fluid status.

Conclusion

In this small pilot study, noninvasive assessment of %LW was sufficiently sensitive to detect pre-to-post hemodialysis change in fluid status. These results support future evaluations in larger studies of patients with ESKD. Noninvasive, wearable devices may be a feasible strategy to assess volume status in the ESKD population, an approach which could potentially be extended to at-home settings.