Scholarlink

Objective <p>The transmission of infectious agents through hemodialysis is one of this critical treatment’s most significant side effects. Human T-lymphotropic virus 1 (HTLV-1) is an endemic oncogenic virus in Iran. Due to its relatively lower prevalence, the infection with this virus is not routinely screened for in patients before hemodialysis. In this study, we aimed to evaluate the seropositivity of HTLV-1 in hemodialysis-dependent patients of Iran to better understand how this treatment can help the virus spread.</p> Methods <p>A comprehensive systematic review and meta-analysis were performed by searching PubMed, Scopus, Google Scholar, and Web of Science databases for studies on the prevalence of HTLV-1 among hemodialysis-dependent patients. The meta-analysis was conducted using R.</p> Results <p>Twelve studies were included. Overall, the prevalence of HTLV1 among patients dependent on hemodialysis treatment was 2.37% (I2 = 70.8% /p-value &lt; 0.0001). The funnel plot asymmetry and trim and fill analysis results showed three studies with higher prevalence as outlier results which all were originated in endemic region of Iran, Khorasan. Highlighting the higher prevalence in the endemic areas.</p> Conclusion <p>Considering the significantly higher prevalence of infection with HTLV-1 in hemodialysis-dependent patients compared to the general population of Iran, more efforts seem necessary to prevent the transmission of the virus through this treatment, even considering screening protocols similar to blood transfusion protocols.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

How serious is the risk of HTLV-1 infection in Iranian hemodialysis-dependent patients?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

查看全文
  • Mahdi Mohammaditabar,
  • Mohammad-Moien Forghani-Ramandi,
  • Niusha Amirani,
  • Sofia Saidi,
  • Sama Zare,
  • Negin Fathi Hafshejani,
  • Sayed-Hamidreza Mozhgani

摘要

Objective

The transmission of infectious agents through hemodialysis is one of this critical treatment’s most significant side effects. Human T-lymphotropic virus 1 (HTLV-1) is an endemic oncogenic virus in Iran. Due to its relatively lower prevalence, the infection with this virus is not routinely screened for in patients before hemodialysis. In this study, we aimed to evaluate the seropositivity of HTLV-1 in hemodialysis-dependent patients of Iran to better understand how this treatment can help the virus spread.

Methods

A comprehensive systematic review and meta-analysis were performed by searching PubMed, Scopus, Google Scholar, and Web of Science databases for studies on the prevalence of HTLV-1 among hemodialysis-dependent patients. The meta-analysis was conducted using R.

Results

Twelve studies were included. Overall, the prevalence of HTLV1 among patients dependent on hemodialysis treatment was 2.37% (I2 = 70.8% /p-value < 0.0001). The funnel plot asymmetry and trim and fill analysis results showed three studies with higher prevalence as outlier results which all were originated in endemic region of Iran, Khorasan. Highlighting the higher prevalence in the endemic areas.

Conclusion

Considering the significantly higher prevalence of infection with HTLV-1 in hemodialysis-dependent patients compared to the general population of Iran, more efforts seem necessary to prevent the transmission of the virus through this treatment, even considering screening protocols similar to blood transfusion protocols.