Scholarlink

Introduction <p>Clinical laboratories play an important role in the diagnosis and monitoring of chronic kidney disease (CKD). Our aim was to evaluate the performance of qualitative and semi-quantitative albumin-to-creatinine ratio (ACR) and protein-to-creatinine ratio (PCR) test strip results as screening tools for albuminuria in multiple representative patient cohorts.</p> Materials and methods <p>ACR and PCR were evaluated in both cross-sectional (<i>n</i> = 940) and validation (<i>n</i> = 927) patient cohorts. Semi-quantitative urinary ACR and PCR were performed using a UC-3500 instrument (Sysmex, Kobe, Japan). The diagnostic performance of semi-quantitative ACR and PCR was determined using quantitative ACR and PCR as reference method.</p> Results <p>In the cross-sectional cohort, a sensitivity and specificity of 78.1% and 93.3%, respectively, were obtained for semi-quantitative ACR at a cut-off of 30&#xa0;mg/g creatinine, with an overall agreement of &gt; 90% between both methods. The sensitivity and specificity increased in the target population (validation cohort) to 89.9% and 92.1%, respectively. In contrast, the sensitivities of qualitative protein concentration (78.6%) and semi-quantitative PCR (69.8%) were lower.</p> Conclusion <p>The results confirm that urine test strip readouts are a valuable screening tool for CKD in low-risk individuals. ACR should be the preferred criterion for reflex testing when using a urine test strip for screening CKD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Optimization of screening strategy for chronic kidney disease by urine test strips using the albumin-creatinine read-out

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月10日

查看全文
  • Stijn Lambrecht,
  • Marijn Speeckaert,
  • Matthijs Oyaert

摘要

Introduction

Clinical laboratories play an important role in the diagnosis and monitoring of chronic kidney disease (CKD). Our aim was to evaluate the performance of qualitative and semi-quantitative albumin-to-creatinine ratio (ACR) and protein-to-creatinine ratio (PCR) test strip results as screening tools for albuminuria in multiple representative patient cohorts.

Materials and methods

ACR and PCR were evaluated in both cross-sectional (n = 940) and validation (n = 927) patient cohorts. Semi-quantitative urinary ACR and PCR were performed using a UC-3500 instrument (Sysmex, Kobe, Japan). The diagnostic performance of semi-quantitative ACR and PCR was determined using quantitative ACR and PCR as reference method.

Results

In the cross-sectional cohort, a sensitivity and specificity of 78.1% and 93.3%, respectively, were obtained for semi-quantitative ACR at a cut-off of 30 mg/g creatinine, with an overall agreement of > 90% between both methods. The sensitivity and specificity increased in the target population (validation cohort) to 89.9% and 92.1%, respectively. In contrast, the sensitivities of qualitative protein concentration (78.6%) and semi-quantitative PCR (69.8%) were lower.

Conclusion

The results confirm that urine test strip readouts are a valuable screening tool for CKD in low-risk individuals. ACR should be the preferred criterion for reflex testing when using a urine test strip for screening CKD.