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Background <p>Despite advances in kidney transplant surgery and immunosuppression, lymphoceles remain a frequent complication in the early postoperative period following kidney transplantation, often requiring reintervention. While long-term outcomes such as patient and allograft survival are well studied, the impact of lymphocele formation on mid-term allograft function remains unclear.</p> Methods <p>This multicentric study included 711 recipients of living donor kidney transplants to investigate the impact of lymphocele formation on mid-term graft function. Outcomes assessed included estimated glomerular filtration rate (eGFR) at 12 months, eGFR slope, and both patient and allograft survival.</p> Results <p>Lymphoceles were detected in 17.4% of the recipients, with a median volume of 129&#xa0;ml, and 71.8% of these patients required intervention. Patients without lymphocele formation had a significantly higher median eGFR at 12 months (52.1&#xa0;ml/min/1.73&#xa0;m²) compared to those with lymphoceles (48.7&#xa0;ml/min/1.73&#xa0;m²). Additionally, patients with lymphocele formation demonstrated a steeper median eGFR slope (-2.3&#xa0;ml/min/1.73&#xa0;m²/year) than those without (-0.3&#xa0;ml/min/1.73&#xa0;m²/year). No significant difference was observed in the composite outcome of allograft survival and patient death between the two groups.</p> Conclusion <p>Lymphocele formation after living donor kidney transplantation is associated with a steeper decline in graft function. They may reflect a disturbed microvasculature and warrant closer control of cardiovascular risk factors and allograft monitoring of affected patients.</p> Clinical trial details <p>Not applicable, the study is not a clinical trial.</p>

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The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月6日

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  • Christian Kuhn,
  • Bernd Jänigen,
  • Laura Matuschik,
  • Max J. Rieger,
  • Daniel Sidler,
  • Stefan Zschiedrich

摘要

Background

Despite advances in kidney transplant surgery and immunosuppression, lymphoceles remain a frequent complication in the early postoperative period following kidney transplantation, often requiring reintervention. While long-term outcomes such as patient and allograft survival are well studied, the impact of lymphocele formation on mid-term allograft function remains unclear.

Methods

This multicentric study included 711 recipients of living donor kidney transplants to investigate the impact of lymphocele formation on mid-term graft function. Outcomes assessed included estimated glomerular filtration rate (eGFR) at 12 months, eGFR slope, and both patient and allograft survival.

Results

Lymphoceles were detected in 17.4% of the recipients, with a median volume of 129 ml, and 71.8% of these patients required intervention. Patients without lymphocele formation had a significantly higher median eGFR at 12 months (52.1 ml/min/1.73 m²) compared to those with lymphoceles (48.7 ml/min/1.73 m²). Additionally, patients with lymphocele formation demonstrated a steeper median eGFR slope (-2.3 ml/min/1.73 m²/year) than those without (-0.3 ml/min/1.73 m²/year). No significant difference was observed in the composite outcome of allograft survival and patient death between the two groups.

Conclusion

Lymphocele formation after living donor kidney transplantation is associated with a steeper decline in graft function. They may reflect a disturbed microvasculature and warrant closer control of cardiovascular risk factors and allograft monitoring of affected patients.

Clinical trial details

Not applicable, the study is not a clinical trial.