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Purpose <p>Transcatheter arterial embolization (TAE) is increasingly utilized in the management of renal angiomyolipomas (AML). However, the growth in its application has not been matched by a proportional increase in the level of evidence validating its safety and efficacy. This meta-analysis aims to evaluate TAE in managing renal AMLs by examining the effects of tumour size reduction and technical success.</p> Methods <p>A literature search of several databases was conducted from inception to July 2023. Eligible studies reported adult patients (≥ 18 years old) who underwent TAE for renal AML. The pooled proportions were analyzed using a random-effects model. This review was registered in PROSPERO (CRD42023441331).</p> Results <p>A total of 32 studies comprising 1087 patients were included. The average preoperative tumour size across renal AMLs was 8.79&#xa0;cm (95% CI: 7.64, 9.93; <i>I</i><sup><i>2</i></sup> = 97%) and the post-operative tumour size was 6.47&#xa0;cm (95% CI: 5.44, 7.50; <i>I</i><sup><i>2</i></sup> = 98%). The mean decrease in tumour size was 1.85&#xa0;cm (95% CI: 1.69, 2.00; <i>I</i><sup><i>2</i></sup> = 23%), whereas the mean reduction in tumour size percentage was 43.30% (95% CI: 34.30, 52.30; <i>I</i><sup><i>2</i></sup> = 98%). The technical success rate from 1059 embolizations was 95.70% (95% CI: 0.94, 0.97; <i>I</i><sup><i>2</i></sup> = 44%), with 65 procedural failures reported.</p> Conclusion <p>This meta-analysis provides insights into the efficacy of TAE for renal AMLs, emphasizing notable tumour size reduction and a high technical success rate for selected patients. Despite identified biases, the findings support TAE as a valuable intervention, warranting further research to refine safety profiles and optimize patient outcomes.</p>

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Safety and efficacy of transcatheter arterial embolization in renal angiomyolipomas: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月31日

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  • Shahid Miangul,
  • Karen Smayra,
  • Liranne Bitton,
  • Reem B. Zalloum,
  • Nathanael Q. E. Yap,
  • Baraa Saad,
  • Rangish Yuvaraj,
  • Marios Alogakos,
  • Hayato Nakanishi,
  • Christian A. Than,
  • Aneeta Parthipun

摘要

Purpose

Transcatheter arterial embolization (TAE) is increasingly utilized in the management of renal angiomyolipomas (AML). However, the growth in its application has not been matched by a proportional increase in the level of evidence validating its safety and efficacy. This meta-analysis aims to evaluate TAE in managing renal AMLs by examining the effects of tumour size reduction and technical success.

Methods

A literature search of several databases was conducted from inception to July 2023. Eligible studies reported adult patients (≥ 18 years old) who underwent TAE for renal AML. The pooled proportions were analyzed using a random-effects model. This review was registered in PROSPERO (CRD42023441331).

Results

A total of 32 studies comprising 1087 patients were included. The average preoperative tumour size across renal AMLs was 8.79 cm (95% CI: 7.64, 9.93; I2 = 97%) and the post-operative tumour size was 6.47 cm (95% CI: 5.44, 7.50; I2 = 98%). The mean decrease in tumour size was 1.85 cm (95% CI: 1.69, 2.00; I2 = 23%), whereas the mean reduction in tumour size percentage was 43.30% (95% CI: 34.30, 52.30; I2 = 98%). The technical success rate from 1059 embolizations was 95.70% (95% CI: 0.94, 0.97; I2 = 44%), with 65 procedural failures reported.

Conclusion

This meta-analysis provides insights into the efficacy of TAE for renal AMLs, emphasizing notable tumour size reduction and a high technical success rate for selected patients. Despite identified biases, the findings support TAE as a valuable intervention, warranting further research to refine safety profiles and optimize patient outcomes.