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Objectives <p>This study aimed to evaluate the diagnostic performance of saline-aided gastroenteric ultrasound (US) for detecting colorectal polyps in pediatric patients.</p> Methods <p>In this single-center, retrospective study (April 2018 to November 2023), we analyzed 466 patients with suspected colorectal polyps. All patients underwent conventional US followed by diagnostic colonoscopy. A consecutive paired cohort (<i>n</i> = 292), enrolled after the introduction of a new protocol, additionally received saline-aided US. Diagnostic metrics (accuracy, sensitivity, specificity) and Cohen’s kappa were calculated to compare conventional and saline-aided US against histopathological reference standards. Multivariate logistic regression was used to assess clinical parameters affecting diagnostic outcomes.</p> Results <p>Among 466 recruited patients (mean age 4.83 ± 3.12 years, 276 males), 391 were colonoscopy-positive. The most common pathological type was juvenile intestinal polyp (93.1%); the most frequent location was the rectum (59.3%). Saline-aided US was associated with improved diagnostic performance (accuracy: 81.8%, sensitivity: 81.0%, specificity: 85.0%) compared to conventional US (accuracy: 51.4%, sensitivity: 39.6%). Multivariate analysis identified polyp size and location as factors significantly associated with diagnostic outcome (both <i>p</i> &lt; 0.001). For saline-aided US, smaller polyps (&lt; 10&#xa0;mm) and those located in the rectum (missed diagnosis rate: 22.8%) were associated with higher rates of missed diagnosis.</p> Conclusion <p>Saline-aided US significantly enhances the detection of colorectal polyps in children, demonstrating superior diagnostic accuracy and sensitivity over conventional US.</p>

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Diagnostic performance of saline-aided ultrasound in the detection of colorectal polyps in children

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月16日

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  • Tong Wang,
  • Haiying Zhou,
  • Tingting Ding,
  • Jia Li,
  • Liezhen Hu,
  • Wei Yu,
  • Meixi Chen,
  • Zhou Lin,
  • Jinlong Deng,
  • Luyao Zhou

摘要

Objectives

This study aimed to evaluate the diagnostic performance of saline-aided gastroenteric ultrasound (US) for detecting colorectal polyps in pediatric patients.

Methods

In this single-center, retrospective study (April 2018 to November 2023), we analyzed 466 patients with suspected colorectal polyps. All patients underwent conventional US followed by diagnostic colonoscopy. A consecutive paired cohort (n = 292), enrolled after the introduction of a new protocol, additionally received saline-aided US. Diagnostic metrics (accuracy, sensitivity, specificity) and Cohen’s kappa were calculated to compare conventional and saline-aided US against histopathological reference standards. Multivariate logistic regression was used to assess clinical parameters affecting diagnostic outcomes.

Results

Among 466 recruited patients (mean age 4.83 ± 3.12 years, 276 males), 391 were colonoscopy-positive. The most common pathological type was juvenile intestinal polyp (93.1%); the most frequent location was the rectum (59.3%). Saline-aided US was associated with improved diagnostic performance (accuracy: 81.8%, sensitivity: 81.0%, specificity: 85.0%) compared to conventional US (accuracy: 51.4%, sensitivity: 39.6%). Multivariate analysis identified polyp size and location as factors significantly associated with diagnostic outcome (both p < 0.001). For saline-aided US, smaller polyps (< 10 mm) and those located in the rectum (missed diagnosis rate: 22.8%) were associated with higher rates of missed diagnosis.

Conclusion

Saline-aided US significantly enhances the detection of colorectal polyps in children, demonstrating superior diagnostic accuracy and sensitivity over conventional US.