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Objective <p>This study aims to investigate the association between the triglyceride glucose (TyG) index and the TyG-to-waist-height ratio (TyG-WHtR) with the risk of all-cause mortality in patients with prior hepatitis A virus (HAV) or hepatitis B virus (HBV) infection.</p> Method <p>This study was a retrospective cohort study that included patients from 1999 to 2018 with available data on HAV/HBV, TyG-related indices, and survival and mortality information. Multiple imputation methods were utilized to address missing variables. A weighted multivariable Cox regression model was employed to analyze the relationship between TyG and TyG-WHtR with all-cause mortality in the study patients. Subgroup analyses were conducted based on age, gender, smoking, diabetes, cardiovascular disease, and hypertension. All analysis results were presented as hazards with a 95% confidence interval (CI).</p> Results <p>The study included a total of 6,413 patients, of which 1,692 were dead. The follow-up period concluded in December 2019, with a total duration of 119.31 ± 1.53 months. Analysis revealed that in patients with prior HAV or HBV infection, the TyG (HR: 1.22, 95%CI: 1.10–1.36) and TyG-WHtR (HR: 1.53, 95%CI: 1.34–1.75) were associated with an increased risk of all-cause mortality. Separate studies conducted in patients with prior HAV or HBV infection also demonstrated an association between the TyG and TyG-WHtR indices with all-cause mortality (former: HR: 1.20, 95%CI: 1.07–1.34; latter: HR: 2.02, 95%CI: 1.49–2.74). Subgroup analysis results indicated that the association between TyG-WHtR and all-cause mortality was similar across age, gender, smoking, and hypertension groups (all <i>P</i> &lt; 0.05).</p> Conclusion <p>In patients with prior HAV or HBV infection, the TyG and TyG-WHtR indices were associated with an increased risk of all-cause mortality. This study underscores the importance of the TyG and TyG-WHtR for patients with prior viral hepatitis, potentially aiding in the improvement of health management for this group.</p> Clinical Trial <p>Our research is not a clinical trial. Clinical trial number: not applicable.</p>

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TyG index and TyG-WHtR as predictors of all-cause mortality in patients with prior hepatitis A or B virus infections

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月24日

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  • Fan Bai,
  • Wen Li,
  • Ni Luo,
  • Yange Li

摘要

Objective

This study aims to investigate the association between the triglyceride glucose (TyG) index and the TyG-to-waist-height ratio (TyG-WHtR) with the risk of all-cause mortality in patients with prior hepatitis A virus (HAV) or hepatitis B virus (HBV) infection.

Method

This study was a retrospective cohort study that included patients from 1999 to 2018 with available data on HAV/HBV, TyG-related indices, and survival and mortality information. Multiple imputation methods were utilized to address missing variables. A weighted multivariable Cox regression model was employed to analyze the relationship between TyG and TyG-WHtR with all-cause mortality in the study patients. Subgroup analyses were conducted based on age, gender, smoking, diabetes, cardiovascular disease, and hypertension. All analysis results were presented as hazards with a 95% confidence interval (CI).

Results

The study included a total of 6,413 patients, of which 1,692 were dead. The follow-up period concluded in December 2019, with a total duration of 119.31 ± 1.53 months. Analysis revealed that in patients with prior HAV or HBV infection, the TyG (HR: 1.22, 95%CI: 1.10–1.36) and TyG-WHtR (HR: 1.53, 95%CI: 1.34–1.75) were associated with an increased risk of all-cause mortality. Separate studies conducted in patients with prior HAV or HBV infection also demonstrated an association between the TyG and TyG-WHtR indices with all-cause mortality (former: HR: 1.20, 95%CI: 1.07–1.34; latter: HR: 2.02, 95%CI: 1.49–2.74). Subgroup analysis results indicated that the association between TyG-WHtR and all-cause mortality was similar across age, gender, smoking, and hypertension groups (all P < 0.05).

Conclusion

In patients with prior HAV or HBV infection, the TyG and TyG-WHtR indices were associated with an increased risk of all-cause mortality. This study underscores the importance of the TyG and TyG-WHtR for patients with prior viral hepatitis, potentially aiding in the improvement of health management for this group.

Clinical Trial

Our research is not a clinical trial. Clinical trial number: not applicable.