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Background <p>Although increasing evidence suggests an association between particulate matter (PM) and tuberculosis (TB), epidemiological studies in southern China remain limited.</p> Methods <p>Daily tuberculosis (TB) case numbers, air pollution, and meteorological data for four cities (Guangzhou, Shenzhen, Foshan and Jiangmen) in southern China during 2015–2019 were collected. A two-stage analytical approach was used to evaluate the association between PM and TB incidence, with stratification by sex, age, disease severity, and city.</p> Results <p>A total of 101,567&#xa0;TB cases were reported in four cities. The relationships between PM<sub>2.5</sub> and PM<sub>10</sub> and TB incidence were approximately linear, with the highest risk observed at a cumulative lag of 0–2 days (lag02). Each 10ug/m<sup>3</sup> increase in PM<sub>2.5</sub> was associated with a 0.84% (95%CI: 0.28%,1.41%) increase in TB incidence, which exceeded the corresponding risk for PM<sub>10</sub> (0.71%, 95%CI: 0.26%, 1.15%). The effect of PM<sub>10</sub> and PM<sub>2.5</sub> on TB incidence appeared to be greater among females, younger individuals, patients with non-severe TB, and residents of Guangzhou and Shenzhen.</p> Conclusions <p>Short-term exposure to ambient PM may significantly increase TB incidence risk in southern China. These findings provide scientific evidence to support the development of integrated TB prevention and air quality management strategies.</p> Clinical trial number <p>Not applicable.</p>

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The short-term effect of particulate matter on tuberculosis: a time-series study in southern China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月8日

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  • Yuhui Chen,
  • Shanshan Huang,
  • Lilian Zeng,
  • Guanhai Li,
  • Keer Ou,
  • Huiying Feng,
  • Xing Li,
  • Anqi Liang,
  • Jianpeng Xiao,
  • Liang Chen,
  • Jiawen Wang

摘要

Background

Although increasing evidence suggests an association between particulate matter (PM) and tuberculosis (TB), epidemiological studies in southern China remain limited.

Methods

Daily tuberculosis (TB) case numbers, air pollution, and meteorological data for four cities (Guangzhou, Shenzhen, Foshan and Jiangmen) in southern China during 2015–2019 were collected. A two-stage analytical approach was used to evaluate the association between PM and TB incidence, with stratification by sex, age, disease severity, and city.

Results

A total of 101,567 TB cases were reported in four cities. The relationships between PM2.5 and PM10 and TB incidence were approximately linear, with the highest risk observed at a cumulative lag of 0–2 days (lag02). Each 10ug/m3 increase in PM2.5 was associated with a 0.84% (95%CI: 0.28%,1.41%) increase in TB incidence, which exceeded the corresponding risk for PM10 (0.71%, 95%CI: 0.26%, 1.15%). The effect of PM10 and PM2.5 on TB incidence appeared to be greater among females, younger individuals, patients with non-severe TB, and residents of Guangzhou and Shenzhen.

Conclusions

Short-term exposure to ambient PM may significantly increase TB incidence risk in southern China. These findings provide scientific evidence to support the development of integrated TB prevention and air quality management strategies.

Clinical trial number

Not applicable.