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Objectives <p>This study aims to examine changes in incidence and mortality in <i>Staphylococcus aureus</i> bacteraemia (SAB) over time and between sexes, describe clinical characteristics and asses their associations with 30-day mortality.</p> Methods <p>We included 837 first-time SAB episodes from 1996 to 2022 in patients aged 18 years or older recorded in the Nord-Trøndelag Hospital Trust Sepsis Registry. Logistic regression was used to investigate time trends and associations with mortality. The study period was divided into early- (1996–2004), mid- (2005–2013) and late- (2014–2022) periods, and results are reported for each period and overall.</p> Results <p>The incidence of SAB increased from 20.0 to 40.3 per 100 000 person years from the early- to the late periods, with males accounting for 522 (62.4%) of all cases. Mortality decreased from 22.6% to 19.0% in males and 29.2% to 20.0% in females. Higher age, malignancy, congestive heart failure, pulmonary infection focus, and unknown focus were associated with increased 30-days mortality.</p> Conclusion <p>The incidence rate of SAB increased significantly from 1996 to 2022, with a consistently higher rate in males compared to females. While the highest mortality rate was observed in females in the earliest period, the mortality rate was similar between the sexes in the last period. The decline in mortality occurred despite an ageing patient population and a stable burden of comorbidities. With the exception of age, none of the variables associated with increased or decreased mortality changed significantly over time.</p> Clinical trial number <p>Not applicable.</p>

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Long-term trends in incidence and mortality in Staphylococcus aureus bacteraemia; a retrospective population-based study from Central Norway 1996–2022

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  • 发表日期：

    2026年4月22日

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  • Ingvild Haugan,
  • Helene Marie Flatby,
  • Birgitta Ehrnström,
  • Nina Vibeche Skei,
  • Randi Marie Mohus,
  • Erik Solligård,
  • Frode Width Gran,
  • Lise Tuset Gustad,
  • Stian Lydersen,
  • Christina Gabrielsen Ås,
  • Jan Kristian Damås,
  • Jan Egil Afset

摘要

Objectives

This study aims to examine changes in incidence and mortality in Staphylococcus aureus bacteraemia (SAB) over time and between sexes, describe clinical characteristics and asses their associations with 30-day mortality.

Methods

We included 837 first-time SAB episodes from 1996 to 2022 in patients aged 18 years or older recorded in the Nord-Trøndelag Hospital Trust Sepsis Registry. Logistic regression was used to investigate time trends and associations with mortality. The study period was divided into early- (1996–2004), mid- (2005–2013) and late- (2014–2022) periods, and results are reported for each period and overall.

Results

The incidence of SAB increased from 20.0 to 40.3 per 100 000 person years from the early- to the late periods, with males accounting for 522 (62.4%) of all cases. Mortality decreased from 22.6% to 19.0% in males and 29.2% to 20.0% in females. Higher age, malignancy, congestive heart failure, pulmonary infection focus, and unknown focus were associated with increased 30-days mortality.

Conclusion

The incidence rate of SAB increased significantly from 1996 to 2022, with a consistently higher rate in males compared to females. While the highest mortality rate was observed in females in the earliest period, the mortality rate was similar between the sexes in the last period. The decline in mortality occurred despite an ageing patient population and a stable burden of comorbidities. With the exception of age, none of the variables associated with increased or decreased mortality changed significantly over time.

Clinical trial number

Not applicable.