Scholarlink

Background <p>Intravesical Bacillus Calmette-Guérin (BCG) therapy is an established treatment for non-muscle-invasive bladder cancer, involving direct instillation of a solution containing attenuated <i>Mycobacterium bovis</i> into the bladder. Although generally well-tolerated, rare vascular complications, including mycotic aneurysms and aortoenteric fistulas, have been reported.</p> Case presentation <p>We report the case of a 76-year-old Japanese man who developed an aortoesophageal fistula three years after completing intravesical BCG therapy for superficial bladder carcinoma. The patient initially presented with bilateral lower limb pain following thoracic endovascular aortic repair. During hospitalization for lumbar pyogenic spondylitis, <i>M. bovis</i> was isolated from both sputum and spine biopsy cultures and confirmed using single-nucleotide polymorphism analysis. Despite the initiation of antimycobacterial therapy with rifampicin, isoniazid, ethambutol, and levofloxacin, he developed hematemesis and upper abdominal pain. Computed tomography findings were highly suggestive of an aortoesophageal fistula. The patient underwent successful surgical repair followed by a prolonged course of antimycobacterial therapy for at least ten months.</p> Conclusions <p>To our knowledge, this is the first documented case of an aortoesophageal fistula caused by <i>M. bovis</i> following intravesical BCG therapy. Clinicians should maintain a high index of suspicion for this life-threatening complication in patients presenting with vascular abnormalities, hematemesis, or abdominal pain following BCG therapy, regardless of the time interval since treatment. Early recognition and aggressive management are essential for improving the outcomes of this rare but life-threatening condition.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Aortoesophageal fistula caused by Mycobacterium bovis following intravesical Bacillus Calmette-Guérin therapy: a case report and literature review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月16日

查看全文
  • Taro Koshiba,
  • Mariko Hakamata,
  • Yusuke Tomita,
  • Ikumi Yamagishi,
  • Masahiro Ui,
  • Hayato Tsuruma,
  • Yuuki Bamba,
  • Hideyuki Ogata,
  • Satoshi Shibata,
  • Hiromi Cho,
  • Mizuho Sato,
  • Nobumasa Aoki,
  • Hiroshi Moro,
  • Akihiro Yoshitake,
  • Toshiaki Kikuchi

摘要

Background

Intravesical Bacillus Calmette-Guérin (BCG) therapy is an established treatment for non-muscle-invasive bladder cancer, involving direct instillation of a solution containing attenuated Mycobacterium bovis into the bladder. Although generally well-tolerated, rare vascular complications, including mycotic aneurysms and aortoenteric fistulas, have been reported.

Case presentation

We report the case of a 76-year-old Japanese man who developed an aortoesophageal fistula three years after completing intravesical BCG therapy for superficial bladder carcinoma. The patient initially presented with bilateral lower limb pain following thoracic endovascular aortic repair. During hospitalization for lumbar pyogenic spondylitis, M. bovis was isolated from both sputum and spine biopsy cultures and confirmed using single-nucleotide polymorphism analysis. Despite the initiation of antimycobacterial therapy with rifampicin, isoniazid, ethambutol, and levofloxacin, he developed hematemesis and upper abdominal pain. Computed tomography findings were highly suggestive of an aortoesophageal fistula. The patient underwent successful surgical repair followed by a prolonged course of antimycobacterial therapy for at least ten months.

Conclusions

To our knowledge, this is the first documented case of an aortoesophageal fistula caused by M. bovis following intravesical BCG therapy. Clinicians should maintain a high index of suspicion for this life-threatening complication in patients presenting with vascular abnormalities, hematemesis, or abdominal pain following BCG therapy, regardless of the time interval since treatment. Early recognition and aggressive management are essential for improving the outcomes of this rare but life-threatening condition.