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Background <p>The lactate-to-albumin ratio (LAR) is correlated with mortality in critically ill patients; however, its predictive value for sepsis in the elderly remains underexplored.</p> Methods <p>This retrospective cohort study used the data from the MIMIC-IV database. The primary outcome was 28-day ICU mortality in elderly patients with sepsis. We used multivariate logistic regression, restricted cubic splines (RCS), subgroup analyses, and machine learning (LightGBM/XGBoost/SVM) to assess the predictive capacity of LAR.</p> Results <p>Among 5,115 eligible patients, elevated log (LAR) independently predicted mortality, as a continuous variable (adjusted odds ratio [OR] = 3.29; 95% confidence interval [CI]: 2.51–4.31; <i>p</i> &lt; 0.001) and in quartiles (Q4 vs. Q1: adjusted OR = 2.11; 95% CI: 1.72–2.59). The RCS indicated a linear LAR-mortality association (p for nonlinear = 0.12). Subgroup analyses confirmed consistency across strata (interaction, <i>p</i> &gt; 0.05). The LightGBM model achieved optimal discriminative performance (area under the curve = 0.788), with log (LAR) as the second-most important feature after the Simplified Acute Physiology Score II.</p> Conclusion <p>LAR is an independent predictor of 28-day mortality in elderly patients with sepsis, despite its limited standalone use. Our LightGBM-based integrative model demonstrated a robust prognostic performance and may aid in clinical decision-making and pending external validation.</p> Clinical trail number <p>Not applicable.</p>

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Association of lactate-to-albumin ratio with 28-day mortality in elderly sepsis patients: a retrospective MIMIC-IV database analysis

  • 期刊论文

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  • 发表日期：

    2026年2月4日

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  • Minhui Dai,
  • Bowen Yuan,
  • Yun Tan

摘要

Background

The lactate-to-albumin ratio (LAR) is correlated with mortality in critically ill patients; however, its predictive value for sepsis in the elderly remains underexplored.

Methods

This retrospective cohort study used the data from the MIMIC-IV database. The primary outcome was 28-day ICU mortality in elderly patients with sepsis. We used multivariate logistic regression, restricted cubic splines (RCS), subgroup analyses, and machine learning (LightGBM/XGBoost/SVM) to assess the predictive capacity of LAR.

Results

Among 5,115 eligible patients, elevated log (LAR) independently predicted mortality, as a continuous variable (adjusted odds ratio [OR] = 3.29; 95% confidence interval [CI]: 2.51–4.31; p < 0.001) and in quartiles (Q4 vs. Q1: adjusted OR = 2.11; 95% CI: 1.72–2.59). The RCS indicated a linear LAR-mortality association (p for nonlinear = 0.12). Subgroup analyses confirmed consistency across strata (interaction, p > 0.05). The LightGBM model achieved optimal discriminative performance (area under the curve = 0.788), with log (LAR) as the second-most important feature after the Simplified Acute Physiology Score II.

Conclusion

LAR is an independent predictor of 28-day mortality in elderly patients with sepsis, despite its limited standalone use. Our LightGBM-based integrative model demonstrated a robust prognostic performance and may aid in clinical decision-making and pending external validation.

Clinical trail number

Not applicable.