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Introduction <p>Due to the lack of effective antiviral treatments for respiratory syncytial virus, therefore, understanding the age-specific disparities in the burden of RSV infection can help identify targeted interventions.</p> Methods <p>This study stratified pediatric patients with RSV-related hospitalizations by age and compared demographic information, clinical features, imaging data, treatment, and outcomes.</p> Results <p>The prevalence of RSV infection was higher in preterm infants under 2 years of age compared to those over 2 years. Among children over 1 year, the proportion with atopic disorders was higher. Cough was the most frequent symptom across all age groups. Cyanosis, dyspnea and wheezing were more common in children under 1 year of age. With increasing age, while the proportion of children with tachypnea increased in children over 5 years of age, and higher incidence of lung consolidation and pleural fluid, who also had a higher non-invasive ventilation.</p> Conclusion <p>Preterm infants require protective measures against RSV infection during the first two years of life. Children over 1 year of age with atopic disorders should receive enhanced preventive care. Greater attention should be given to tachypnea, lung consolidation, pleural fluid in children over 5 years of age.</p>

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Research on age-stratified prevention and control strategies for pediatric RSV infection based on disease burden disparities

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月19日

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  • Jingwen Ni,
  • Junyu Dong,
  • Zhihui Du,
  • Mengxin Zhao,
  • Lele Li,
  • Xiaoqiao Zhang,
  • Kenan Fang

摘要

Introduction

Due to the lack of effective antiviral treatments for respiratory syncytial virus, therefore, understanding the age-specific disparities in the burden of RSV infection can help identify targeted interventions.

Methods

This study stratified pediatric patients with RSV-related hospitalizations by age and compared demographic information, clinical features, imaging data, treatment, and outcomes.

Results

The prevalence of RSV infection was higher in preterm infants under 2 years of age compared to those over 2 years. Among children over 1 year, the proportion with atopic disorders was higher. Cough was the most frequent symptom across all age groups. Cyanosis, dyspnea and wheezing were more common in children under 1 year of age. With increasing age, while the proportion of children with tachypnea increased in children over 5 years of age, and higher incidence of lung consolidation and pleural fluid, who also had a higher non-invasive ventilation.

Conclusion

Preterm infants require protective measures against RSV infection during the first two years of life. Children over 1 year of age with atopic disorders should receive enhanced preventive care. Greater attention should be given to tachypnea, lung consolidation, pleural fluid in children over 5 years of age.