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Background <p><i>Toxoplasma gondii</i> infects nearly one-third of the global population and has been implicated in neurologic dysfunction; however, its contribution to Parkinson’s disease (PD) remains unresolved.</p> Aim <p>Here we assess whether <i>T. gondii</i> seropositivity is associated with PD occurrence or severity in a well-defined group of patients and matched controls.</p> Methods <p>A case–control design included <i>n</i> = 60 PD patients and <i>n</i> = 60 matched controls, with anti-<i>T. gondii</i> IgG/IgM quantified by ELISA and PD severity graded using the Hoehn and Yahr scale. Logistic regression evaluated associations (<i>P</i> &lt; 0.05).</p> Results <p>Among 120 participants (60 PD, 60 controls; mean age 69.7 ± 9.0 years; 66.7% male), education differed significantly (illiteracy: 58.3% vs. 30.0%, <i>p</i> &lt; 0.001). Risk factors for <i>T. gondii</i> infection showed no significant differences: cat contact (61.7% vs. 56.7%; OR = 1.22, 95% CI: 0.57–2.62), unwashed vegetables (20.0% vs. 21.7%; OR = 0.90, 95% CI: 0.36–2.25), and undercooked meat (15.0% vs. 16.7%; OR = 0.88, 95% CI: 0.30–2.57). Overall IgG seroprevalence was 90.8% (PD 88.3%, controls 93.3%; adjusted OR = 0.56, 95% CI: 0.16–1.94, <i>p</i> = 0.36). IgG positivity did not vary significantly by PD severity (85.7–100% across Hoehn and Yahr stages), and only one PD patient was IgM-positive.</p> Conclusions <p>The data establish that chronic <i>T. gondii</i> exposure does not differentiate PD patients from controls and does not convincingly modulate disease severity. This work provides a new framework for interpreting parasite–neurodegeneration links in high-exposure settings and opens the door to future studies using molecular assays and longitudinal designs to resolve causal pathways.</p>

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Investigating the prevalence of Toxoplasma gondii infection in Parkinson’s disease patients and its association with disease severity: a case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月12日

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  • Lotfollah Davoodi,
  • Mehran Frouzanian,
  • Eissa Soleymani,
  • Mohammadreza Dehghan Nejad,
  • Amirsaleh Abdollahi

摘要

Background

Toxoplasma gondii infects nearly one-third of the global population and has been implicated in neurologic dysfunction; however, its contribution to Parkinson’s disease (PD) remains unresolved.

Aim

Here we assess whether T. gondii seropositivity is associated with PD occurrence or severity in a well-defined group of patients and matched controls.

Methods

A case–control design included n = 60 PD patients and n = 60 matched controls, with anti-T. gondii IgG/IgM quantified by ELISA and PD severity graded using the Hoehn and Yahr scale. Logistic regression evaluated associations (P < 0.05).

Results

Among 120 participants (60 PD, 60 controls; mean age 69.7 ± 9.0 years; 66.7% male), education differed significantly (illiteracy: 58.3% vs. 30.0%, p < 0.001). Risk factors for T. gondii infection showed no significant differences: cat contact (61.7% vs. 56.7%; OR = 1.22, 95% CI: 0.57–2.62), unwashed vegetables (20.0% vs. 21.7%; OR = 0.90, 95% CI: 0.36–2.25), and undercooked meat (15.0% vs. 16.7%; OR = 0.88, 95% CI: 0.30–2.57). Overall IgG seroprevalence was 90.8% (PD 88.3%, controls 93.3%; adjusted OR = 0.56, 95% CI: 0.16–1.94, p = 0.36). IgG positivity did not vary significantly by PD severity (85.7–100% across Hoehn and Yahr stages), and only one PD patient was IgM-positive.

Conclusions

The data establish that chronic T. gondii exposure does not differentiate PD patients from controls and does not convincingly modulate disease severity. This work provides a new framework for interpreting parasite–neurodegeneration links in high-exposure settings and opens the door to future studies using molecular assays and longitudinal designs to resolve causal pathways.