Scholarlink

Background <p>Coagulopathy, a frequent complication of infectious diseases, is strongly associated with adverse clinical outcomes. This study aimed to investigate the prognostic value of prothrombin time activity (PTA) in patients with infective endocarditis (IE).</p> Methods <p>A total of 1,533 IE patients were stratified into four groups based on quartiles of PTA at admission: 1) &lt; 73% (<i>n</i> = 366); 2) 73%-83% (<i>n</i> = 381); 3) 84%-92% (<i>n</i> = 370); and 4) ≥ 93% (<i>n</i> = 416). Receiver operating characteristic (ROC) analysis was used to identify the optimal PTA cut-off for predicting in-hospital mortality. Multivariable regression and subgroup analyses were conducted to assess the association between PTA and 6-month mortality.</p> Results <p>The in-hospital mortality was higher in IE patients with lower PTA (15.8% vs. 5.8% vs. 4.6% vs. 2.9%; <i>P</i> &lt; 0.001). PTA was independently associated with in-hospital death (odds ratio: 0.98; 95% CI: 0.97-0.99; <i>P</i> &lt; 0.001). ROC curve analysis identified 78% as the optimal PTA cut-off value for predicting in-hospital mortality, with a sensitivity of 67.8% and specificity of 66.1% (AUC: 0.704; <i>P</i> &lt; <i>0.001</i>). In multivariable Cox regression analysis, PTA &lt; 78% was an independent predictor of 6-month mortality, with a 2.27-fold increased risk after adjusting for potential confounders (95% CI: 1.63-3.17; <i>P</i> = 0.025). The predictive performance of PTA was robust across subgroups stratified by infection site, disease severity, and organ dysfunction.</p> Conclusion <p>PTA &lt; 78% at admission is an independent predictor of poor short-term outcomes in patients with IE. This novel finding highlights the importance of coagulation assessment in IE and facilitates early risk stratification in IE management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between prothrombin time activity and short-term outcomes in patients with infective endocarditis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月29日

查看全文
  • Jingwen Li,
  • Shuaizheng Che,
  • Qiming Xie,
  • Jielei Yang,
  • Junquan Lu,
  • Di Wu,
  • Danqing Yu,
  • Xuebiao Wei

摘要

Background

Coagulopathy, a frequent complication of infectious diseases, is strongly associated with adverse clinical outcomes. This study aimed to investigate the prognostic value of prothrombin time activity (PTA) in patients with infective endocarditis (IE).

Methods

A total of 1,533 IE patients were stratified into four groups based on quartiles of PTA at admission: 1) < 73% (n = 366); 2) 73%-83% (n = 381); 3) 84%-92% (n = 370); and 4) ≥ 93% (n = 416). Receiver operating characteristic (ROC) analysis was used to identify the optimal PTA cut-off for predicting in-hospital mortality. Multivariable regression and subgroup analyses were conducted to assess the association between PTA and 6-month mortality.

Results

The in-hospital mortality was higher in IE patients with lower PTA (15.8% vs. 5.8% vs. 4.6% vs. 2.9%; P < 0.001). PTA was independently associated with in-hospital death (odds ratio: 0.98; 95% CI: 0.97-0.99; P < 0.001). ROC curve analysis identified 78% as the optimal PTA cut-off value for predicting in-hospital mortality, with a sensitivity of 67.8% and specificity of 66.1% (AUC: 0.704; P < 0.001). In multivariable Cox regression analysis, PTA < 78% was an independent predictor of 6-month mortality, with a 2.27-fold increased risk after adjusting for potential confounders (95% CI: 1.63-3.17; P = 0.025). The predictive performance of PTA was robust across subgroups stratified by infection site, disease severity, and organ dysfunction.

Conclusion

PTA < 78% at admission is an independent predictor of poor short-term outcomes in patients with IE. This novel finding highlights the importance of coagulation assessment in IE and facilitates early risk stratification in IE management.