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Background <p>Early-onset prosthetic valve endocarditis (EO-PVE) is linked to poor in-hospital outcomes. Staphylococcus spp. poses a significant concern due to its higher mortality rates compared to other major infectious agents.</p> Objectives <p>Provide a more detailed, comprehensive evaluation of the clinical characteristics and in-hospital mortality predictors related to staphylococcal EO-PVE.</p> Methods <p>This observational, retrospective, single-center study was conducted at a tertiary hospital in Brazil from 1997 to 2019, spanning a 22-year period. A total of 105 consecutive cases of left-heart staphylococcal EO-PVE were analyzed.</p> Results <p>There was a predominance of coagulase-negative staphylococci prosthetic valve endocarditis (CoNS PVE) over Staphylococcus aureus prosthetic valve endocarditis (SAPVE) (76% and 24%, respectively). Prosthetic valve replacement for EO-PVE treatment was performed in 73% of cases. In-hospital mortality was 49%, with SAPVE associated with a higher in-hospital mortality than CoNS PVE (80% versus 43%, <i>p</i> &lt; 0.001). In-hospital mortality predictors identified by univariate analysis included older age (<i>p</i> &lt; 0.001), aortic prosthetic endocarditis (<i>p</i> &lt; 0.001), peri-annular abscess (<i>p</i> = 0.002), SAPVE (<i>p</i> &lt; 0.001), NYHA functional class III/IV (<i>p</i> = 0.02), previous combined myocardial revascularization with valve replacement surgery (<i>p</i> = 0.02), left ventricular dysfunction (<i>p</i> &lt; 0.001), leukocytosis (<i>p</i> = 0.02), and higher C-reactive protein levels (<i>p</i> = 0.006). In a multivariate analysis, SAPVE was identified as an independent risk factor for in-hospital mortality (odds ratio [OR] 10.2; <i>p</i> = 0.006), whereas prosthetic valve replacement was associated with improved in-hospital survival (OR 0.2; <i>p</i> = 0.04).</p> Conclusion <p>Staphylococcal EO-PVE is associated with increased in-hospital mortality, particularly in SAPVE cases. In this study, all non-operated SAPVE patients died primarily due to fulminant septic shock. Prosthetic valve replacement was significantly linked to in-hospital survival, and only 5.7% of the study population survived without cardiac surgical intervention.</p> Clinical trial number <p>Not applicable.</p>

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Staphylococcal early-onset prosthetic valve endocarditis: a condition bound for surgery

  • 期刊论文

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  • 发表日期：

    2025年12月19日

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  • Antonio de Santis,
  • Eduardo Cukierkorn,
  • Flavio Tarasoutchi,
  • Roney Orismar Sampaio,
  • Tshimbalanga Merite,
  • Milena R. Paixão,
  • Carlos Manuel A. Brandão,
  • Elinthon T. Veronese,
  • Francisco Monteiro de Almeida Magalhães,
  • Tarso A. D. Accorsi,
  • Guilherme S. Spina,
  • Tania Mara Varejão Strabelli,
  • Rinaldo Focaccia Siciliano

摘要

Background

Early-onset prosthetic valve endocarditis (EO-PVE) is linked to poor in-hospital outcomes. Staphylococcus spp. poses a significant concern due to its higher mortality rates compared to other major infectious agents.

Objectives

Provide a more detailed, comprehensive evaluation of the clinical characteristics and in-hospital mortality predictors related to staphylococcal EO-PVE.

Methods

This observational, retrospective, single-center study was conducted at a tertiary hospital in Brazil from 1997 to 2019, spanning a 22-year period. A total of 105 consecutive cases of left-heart staphylococcal EO-PVE were analyzed.

Results

There was a predominance of coagulase-negative staphylococci prosthetic valve endocarditis (CoNS PVE) over Staphylococcus aureus prosthetic valve endocarditis (SAPVE) (76% and 24%, respectively). Prosthetic valve replacement for EO-PVE treatment was performed in 73% of cases. In-hospital mortality was 49%, with SAPVE associated with a higher in-hospital mortality than CoNS PVE (80% versus 43%, p < 0.001). In-hospital mortality predictors identified by univariate analysis included older age (p < 0.001), aortic prosthetic endocarditis (p < 0.001), peri-annular abscess (p = 0.002), SAPVE (p < 0.001), NYHA functional class III/IV (p = 0.02), previous combined myocardial revascularization with valve replacement surgery (p = 0.02), left ventricular dysfunction (p < 0.001), leukocytosis (p = 0.02), and higher C-reactive protein levels (p = 0.006). In a multivariate analysis, SAPVE was identified as an independent risk factor for in-hospital mortality (odds ratio [OR] 10.2; p = 0.006), whereas prosthetic valve replacement was associated with improved in-hospital survival (OR 0.2; p = 0.04).

Conclusion

Staphylococcal EO-PVE is associated with increased in-hospital mortality, particularly in SAPVE cases. In this study, all non-operated SAPVE patients died primarily due to fulminant septic shock. Prosthetic valve replacement was significantly linked to in-hospital survival, and only 5.7% of the study population survived without cardiac surgical intervention.

Clinical trial number

Not applicable.