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Introduction <p>In Bangladesh, the antibiotic resistance patterns of uropathogens in patients with complicated urinary tract infections (cUTIs) remain poorly understood. This study aimed to identify the most prevalent bacteria in urine samples from cUTI patients and assess their resistance to commonly used antibiotics.</p> Method <p>Between January 2023 and June 2024, we conducted this retrospective cross-sectional study among patients from the Nephrology department of Bangladesh Medical College Hospital, Dhaka. Clinical and microbiological data were retrieved for adult patients with culture-confirmed UTI (≥ 10⁵ CFU/mL). Reports from patients with at least one documented complicating factor were included in the analysis. The antibiotic susceptibility of 31 commonly used antibiotics was evaluated using the standard Kirby-Bauer method. Descriptive statistics were used to summarize bacterial isolates, patient demographics, complicating factors, and antibiotic sensitivity patterns. Inferential tests were performed to assess associations between risk factors and specific pathogens.</p> Results <p>A total of 170 urine culture-positive samples from eligible patients were included in this study. <i>E. coli</i> was the most prevalent pathogen (49%) observed, followed by <i>K. pneumoniae</i> (25%) and <i>P. aeruginosa</i> (10%). Female patients accounted for 65% of cases. Diabetes mellitus (66%) was the most prevalent complicating factor, along with the presence of renal stone (16%) and an indwelling urinary catheter (11%). <i>P. aeruginosa</i> was significantly more common in diabetic and transplant patients. Antibiotic susceptibility testing revealed high resistance among <i>E. coli</i> and <i>K. pneumoniae</i> to Quinolones (10–55%) and Cephalosporins (4–55%). In contrast, <i>P. aeruginosa</i> showed significant resistance to aminoglycosides (31–63%) and Carbapenems (0–38%).</p> Conclusion <p>This study demonstrates that <i>E. coli</i> and <i>K. pneumoniae</i> are the predominant uropathogens in patients with cUTIs in Bangladesh. Both organisms exhibited notable resistance to Quinolones and the Cephalosporins group of antibiotics. These findings underscore the need for tailored antibiotic stewardship programs to guide appropriate treatment decisions and improve clinical outcomes in cUTI patients.</p>

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Bacterial profile and antibiotic resistance pattern of uropathogens isolated from patients with complicated urinary tract infections in a tertiary care hospital in Dhaka, Bangladesh

  • 期刊论文

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  • 发表日期：

    2025年11月10日

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  • Sonia Mahjabin,
  • Rezwanur Rahman,
  • Ummi Rukaiya Munni,
  • Muntasir Ebne Mobin,
  • Ashrak Shad Pyash,
  • Homayra Rahman Shoshi

摘要

Introduction

In Bangladesh, the antibiotic resistance patterns of uropathogens in patients with complicated urinary tract infections (cUTIs) remain poorly understood. This study aimed to identify the most prevalent bacteria in urine samples from cUTI patients and assess their resistance to commonly used antibiotics.

Method

Between January 2023 and June 2024, we conducted this retrospective cross-sectional study among patients from the Nephrology department of Bangladesh Medical College Hospital, Dhaka. Clinical and microbiological data were retrieved for adult patients with culture-confirmed UTI (≥ 10⁵ CFU/mL). Reports from patients with at least one documented complicating factor were included in the analysis. The antibiotic susceptibility of 31 commonly used antibiotics was evaluated using the standard Kirby-Bauer method. Descriptive statistics were used to summarize bacterial isolates, patient demographics, complicating factors, and antibiotic sensitivity patterns. Inferential tests were performed to assess associations between risk factors and specific pathogens.

Results

A total of 170 urine culture-positive samples from eligible patients were included in this study. E. coli was the most prevalent pathogen (49%) observed, followed by K. pneumoniae (25%) and P. aeruginosa (10%). Female patients accounted for 65% of cases. Diabetes mellitus (66%) was the most prevalent complicating factor, along with the presence of renal stone (16%) and an indwelling urinary catheter (11%). P. aeruginosa was significantly more common in diabetic and transplant patients. Antibiotic susceptibility testing revealed high resistance among E. coli and K. pneumoniae to Quinolones (10–55%) and Cephalosporins (4–55%). In contrast, P. aeruginosa showed significant resistance to aminoglycosides (31–63%) and Carbapenems (0–38%).

Conclusion

This study demonstrates that E. coli and K. pneumoniae are the predominant uropathogens in patients with cUTIs in Bangladesh. Both organisms exhibited notable resistance to Quinolones and the Cephalosporins group of antibiotics. These findings underscore the need for tailored antibiotic stewardship programs to guide appropriate treatment decisions and improve clinical outcomes in cUTI patients.