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Objective <p>To analyse the clinical characteristics, antifungal drug resistance, and prognostic factors of patients with <i>Candida auris</i> bloodstream infection. Explore targeted nursing strategies, and provide reference for clinical diagnosis, treatment, and nursing.</p> Methods <p>Clinical data were collected from 11 patients with <i>C.auris</i> bloodstream infections admitted to Guangdong Provincial Second Hospital of Traditional Chinese Medicine between January 2023 and June 2025. The data included underlying diseases, history of invasive procedures, antibiotic use, treatment regimens, laboratory indicators, etc. Use a self-made form to collect patient care measures and track their condition. The clinical characteristics of the patients and factors affecting their prognosis were analysed.</p> Results <p>Among the 11 patients, males accounted for 90.9%, with a mean age of 62 years; They were primarily distributed across the Acupuncture Rehabilitation Department and the Intensive Care Unit (ICU); 8 patients had pneumonia, 10 patients had peripherally inserted central venous catheter(PICC), and 9 patients had used antibiotics before infection; 7 patients received targeted treatment, including 6 patients who used caspofungin. Antimicrobial susceptibility testing revealed a fluconazole resistance rate of 81.8%. In terms of prognosis, 6 cases were in the good prognosis group and 5 cases were in the poor prognosis group; the neutrophil-to-albumin ratio (NPAR) was significantly lower in the poor prognosis group than in the good prognosis group (<i>P</i> = 0.006). In terms of nursing measures, there was no statistically significant difference in targeted nursing measures between patients with different prognoses. However, differentiated nursing care can be provided based on patients’ underlying conditions, NPAR values, and other factors.</p> Conclusion <p>Patients with <i>C.auris</i> bloodstream infections are predominantly males with underlying medical conditions, who have undergone invasive procedures and been exposed to antibiotics. NPAR can serve as a prognostic assessment indicator. Enhanced care during invasive procedures, infection control measures, and targeted disease monitoring are effective strategies for preventing healthcare-associated infections and improving patient outcomes.</p>

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Analysis of the clinical characteristics and nursing strategies for 11 cases of Candida auris bloodstream infection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月31日

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  • Yan Duan,
  • Chuangchuang Mei,
  • Xiaojing Hong,
  • Donghao Cai,
  • Xiaojun Li

摘要

Objective

To analyse the clinical characteristics, antifungal drug resistance, and prognostic factors of patients with Candida auris bloodstream infection. Explore targeted nursing strategies, and provide reference for clinical diagnosis, treatment, and nursing.

Methods

Clinical data were collected from 11 patients with C.auris bloodstream infections admitted to Guangdong Provincial Second Hospital of Traditional Chinese Medicine between January 2023 and June 2025. The data included underlying diseases, history of invasive procedures, antibiotic use, treatment regimens, laboratory indicators, etc. Use a self-made form to collect patient care measures and track their condition. The clinical characteristics of the patients and factors affecting their prognosis were analysed.

Results

Among the 11 patients, males accounted for 90.9%, with a mean age of 62 years; They were primarily distributed across the Acupuncture Rehabilitation Department and the Intensive Care Unit (ICU); 8 patients had pneumonia, 10 patients had peripherally inserted central venous catheter(PICC), and 9 patients had used antibiotics before infection; 7 patients received targeted treatment, including 6 patients who used caspofungin. Antimicrobial susceptibility testing revealed a fluconazole resistance rate of 81.8%. In terms of prognosis, 6 cases were in the good prognosis group and 5 cases were in the poor prognosis group; the neutrophil-to-albumin ratio (NPAR) was significantly lower in the poor prognosis group than in the good prognosis group (P = 0.006). In terms of nursing measures, there was no statistically significant difference in targeted nursing measures between patients with different prognoses. However, differentiated nursing care can be provided based on patients’ underlying conditions, NPAR values, and other factors.

Conclusion

Patients with C.auris bloodstream infections are predominantly males with underlying medical conditions, who have undergone invasive procedures and been exposed to antibiotics. NPAR can serve as a prognostic assessment indicator. Enhanced care during invasive procedures, infection control measures, and targeted disease monitoring are effective strategies for preventing healthcare-associated infections and improving patient outcomes.