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Background <p>COVID-19 vaccines have been crucial for establishing immunity; however, emerging data suggest vaccine efficacy is reduced within six months. Healthcare staff face an elevated COVID-19 risk and should make an informed decision to receive timely boosters to maintain their immunity.</p> <p>This study aims to determine the COVID-19 neutralizing antibody (nAb) seroprevalence among primary care staff and the impact of serological testing on their vaccination decision.</p> Methods <p>This cross-sectional study involved multidisciplinary primary healthcare professionals working in 10 public primary care clinics from December 2022 to July 2023. A questionnaire captured sociodemographic data, COVID-19 related history and attitudes toward serological testing. Their COVID-19 nAb levels were measured via point-of-care CoVIm™ Rapid SARS-CoV-2 nAb Test and laboratory cPass™ SARS-CoV-2 nAb Detection Kit.</p> Results <p>The study included 474 subjects, mostly female (88.8%), with a mean age of 40.6 years (SD = 12.3). All received at least two COVID-19 vaccinations, and 80.6% reported at least one infection. COVID-19 nAb seroprevalence was high (99.2%). Post-vaccination, 79.7% contracted COVID-19, with the median time to infection being 163 days. Most staff (93.9%) desired to know their COVID-19 immunity status through a finger pick test (77.0%) instead of venepuncture. Over two-thirds (68.1%) indicated the results would influence their booster vaccination decision.</p> Conclusion <p>The study revealed a high seroprevalence of COVID-19 nAb among the fully vaccinated participating staff. The necessity for timely boosters is underscored by 79.7% contracting COVID-19 post-vaccination. Most subjects were willing to undergo point-of-care testing, with results potentially influencing their decisions for booster vaccination.</p>

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Seroprevalence of COVID-19 neutralizing antibodies among multi-ethnic staff of an Asian primary healthcare institution: insights from point-of-care testing and implications for booster vaccination decisions

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月30日

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  • Prawira Oka,
  • Huan Jia,
  • Patthara Kongsuphol,
  • Say Yong Ng,
  • Vivekanandan Saravanan,
  • Chirk Jenn Ng,
  • Aminath Shiwaza Moosa,
  • Mengfei Xiong,
  • Shih Ying Gun,
  • Li Ping Marianne Tsang,
  • Jingyi Lim,
  • Kayshini Vijaykumar,
  • Cassandra Xin Yi Ho,
  • Patrina W. L. Chua,
  • Sharon Y. H. Ling,
  • Megan E. McBee,
  • Peter R. Preiser,
  • Hadley D. Sikes,
  • Ngiap Chuan Tan

摘要

Background

COVID-19 vaccines have been crucial for establishing immunity; however, emerging data suggest vaccine efficacy is reduced within six months. Healthcare staff face an elevated COVID-19 risk and should make an informed decision to receive timely boosters to maintain their immunity.

This study aims to determine the COVID-19 neutralizing antibody (nAb) seroprevalence among primary care staff and the impact of serological testing on their vaccination decision.

Methods

This cross-sectional study involved multidisciplinary primary healthcare professionals working in 10 public primary care clinics from December 2022 to July 2023. A questionnaire captured sociodemographic data, COVID-19 related history and attitudes toward serological testing. Their COVID-19 nAb levels were measured via point-of-care CoVIm™ Rapid SARS-CoV-2 nAb Test and laboratory cPass™ SARS-CoV-2 nAb Detection Kit.

Results

The study included 474 subjects, mostly female (88.8%), with a mean age of 40.6 years (SD = 12.3). All received at least two COVID-19 vaccinations, and 80.6% reported at least one infection. COVID-19 nAb seroprevalence was high (99.2%). Post-vaccination, 79.7% contracted COVID-19, with the median time to infection being 163 days. Most staff (93.9%) desired to know their COVID-19 immunity status through a finger pick test (77.0%) instead of venepuncture. Over two-thirds (68.1%) indicated the results would influence their booster vaccination decision.

Conclusion

The study revealed a high seroprevalence of COVID-19 nAb among the fully vaccinated participating staff. The necessity for timely boosters is underscored by 79.7% contracting COVID-19 post-vaccination. Most subjects were willing to undergo point-of-care testing, with results potentially influencing their decisions for booster vaccination.