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Background and purpose <p>Treating septic shock requires a multifactorial plan, such as anti-inflammatory drugs and newer drugs to reduce inflammation. This study investigated the effect of a combination (statin and vitamin C) on septic shock mortality and disease symptoms.</p> Methods <p>In this double-blind clinical trial study, 60 patients with septic shock hospitalized in the intensive care unit were assigned into two groups: intervention (1 gram of vitamin C was prescribed once a day for 5 days, and atorvastatin 40&#xa0;mg daily) and control (routine treatment). Inflammatory parameters (C-reactive protein (CRP), lactate dehydrogenase (LDH), and serum ferritin (SF) and lactate), patient conditions, and Sequential Organ Failure Assessment (SOFA) scores were monitored and recorded on the fifth and seventh days of hospitalization, and the day of discharge from the intensive care unit (ICU).</p> Results <p>While mortality had no difference between the groups (<i>p</i> &gt; 0.05), the duration of receiving inotrope was significantly shorter in the intervention group (<i>p</i> &lt; 0.05). After the intervention, the measures of SOFA score, CRP, LDH, SF, and Lactate in the intervention group were significantly lower than those of the control group (<i>p</i> &lt; 0.05). Besides, the measures of the biomarkers, including CRP, LDH, and SF, were significantly different in the intervention group (<i>p</i> &lt; 0.05).</p> Conclusion <p>The results of this study showed that the simultaneous use of statin and vitamin C can reduce inflammation indicators in ICU-admitted sepsis patients; however, this short-term intervention had no effect on mortality in the patients.</p>

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The combined effect of statin and vitamin C in patients with pulmonary septic shock: a single-center, double-blind clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月24日

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  • Behrooz Farzanegan,
  • Navid Shafigh,
  • Morteza Hasheminik,
  • Haleh Alipour,
  • Ali Behzadfar,
  • Nava Safaee,
  • Elnaz Shafigh,
  • Mehdi Kazempour Dizaji

摘要

Background and purpose

Treating septic shock requires a multifactorial plan, such as anti-inflammatory drugs and newer drugs to reduce inflammation. This study investigated the effect of a combination (statin and vitamin C) on septic shock mortality and disease symptoms.

Methods

In this double-blind clinical trial study, 60 patients with septic shock hospitalized in the intensive care unit were assigned into two groups: intervention (1 gram of vitamin C was prescribed once a day for 5 days, and atorvastatin 40 mg daily) and control (routine treatment). Inflammatory parameters (C-reactive protein (CRP), lactate dehydrogenase (LDH), and serum ferritin (SF) and lactate), patient conditions, and Sequential Organ Failure Assessment (SOFA) scores were monitored and recorded on the fifth and seventh days of hospitalization, and the day of discharge from the intensive care unit (ICU).

Results

While mortality had no difference between the groups (p > 0.05), the duration of receiving inotrope was significantly shorter in the intervention group (p < 0.05). After the intervention, the measures of SOFA score, CRP, LDH, SF, and Lactate in the intervention group were significantly lower than those of the control group (p < 0.05). Besides, the measures of the biomarkers, including CRP, LDH, and SF, were significantly different in the intervention group (p < 0.05).

Conclusion

The results of this study showed that the simultaneous use of statin and vitamin C can reduce inflammation indicators in ICU-admitted sepsis patients; however, this short-term intervention had no effect on mortality in the patients.