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Background <p><i>Listeria monocytogenes</i> is one of the major bacteria responsible for meningitis. Controversy exists regarding the neuropathological effect of human pegivirus-1 (HPgV-1). Whether HPgV-1 interacts with <i>L. monocytogenes</i> is unknown. Herein, we describe a multiple myeloma patient with disseminated <i>L. monocytogenes</i> and HPgV-1 coinfection.</p> Case presentation <p>The case of a 57-year-old patient with fever accompanied by headache, dizziness, nausea, vomiting of stomach contents, and urinary and faecal incontinence is presented. Through metagenomic next-generation sequencing and the detection of <i>L. monocytogenes</i> and HPgV-1 in cerebrospinal fluid, along with blood culture of <i>L. monocytogenes</i> and PCR of HPgV-1 in the blood, a diagnosis of HPgV-1 and <i>L. monocytogenes</i> meningitis, HPgV-1 viremia, and <i>L. monocytogenes</i> sepsis was made, enabling timely and proper treatment with meropenem. After treatment, the patient recovered and was discharged from the hospital.</p> Conclusions <p>To our knowledge, this is the first reported case of disseminated <i>L. monocytogenes</i> and HPgV-1 coinfection. Determining whether HPgV-1 was responsible for meningitis will require further research, including histopathological analysis.</p>

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Disseminated Listeria monocytogenes and human pegivirus-1 coinfection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月15日

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  • Man Yuan,
  • Xiaoju Lv,
  • Yu Yuan,
  • Mei Kang,
  • Fang He

摘要

Background

Listeria monocytogenes is one of the major bacteria responsible for meningitis. Controversy exists regarding the neuropathological effect of human pegivirus-1 (HPgV-1). Whether HPgV-1 interacts with L. monocytogenes is unknown. Herein, we describe a multiple myeloma patient with disseminated L. monocytogenes and HPgV-1 coinfection.

Case presentation

The case of a 57-year-old patient with fever accompanied by headache, dizziness, nausea, vomiting of stomach contents, and urinary and faecal incontinence is presented. Through metagenomic next-generation sequencing and the detection of L. monocytogenes and HPgV-1 in cerebrospinal fluid, along with blood culture of L. monocytogenes and PCR of HPgV-1 in the blood, a diagnosis of HPgV-1 and L. monocytogenes meningitis, HPgV-1 viremia, and L. monocytogenes sepsis was made, enabling timely and proper treatment with meropenem. After treatment, the patient recovered and was discharged from the hospital.

Conclusions

To our knowledge, this is the first reported case of disseminated L. monocytogenes and HPgV-1 coinfection. Determining whether HPgV-1 was responsible for meningitis will require further research, including histopathological analysis.